Total synthesis of antibiotic C104: Benzyne-Furan cycloaddition approach to the angucyclines

Article abstract of DOI:10.1016/0040-4020(95)00384-K

First total synthesis of antibiotic C104 (1), a prototypical member of the angucyclines, was accomplished. Highly regioselective cycloaddition of α-alkoxybenzyne 12 with angularly fused α-siloxyfuran 10 enabled the straightforward construction of the char