Effect of the linking position of a side chain in bis(quinolylmethyl)ethylenediamine as a DNA binding agent

DOI: 10.1248/cpb.48.477

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 477 - 479 (2000)

Update date:2022-08-24

Topics:

Authors:

Mikata, Yuji

Onchi, Yoko

Kishigami, Maki

Yano, Shigenobu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.48.477

Two bisquinoline derivatives, N,N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N,N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay. These compounds exhibited apparent AT- specificity suggesting minor groove binding in addition to intercalation.

Full text of DOI:10.1248/cpb.48.477

NII-Electronic Library Service

Products guided by the article

Product name:8-Bromomethylquinoline

Cas No:7496-46-0

R&D Labs maybe for 7496-46-0

Hangzhou innopharma technology Co,.Ltd.(expird)

Contact:+86-13388601988

Address:Room845,lixin building, moganshan road, hangzhou, china
Xiamen Hisunny Chemical Co.,Ltd

website:http://www.hisunnychem.com

Contact:+86-592-3327115

Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China
Suzhou Chiral Pharmaceuticals Co., Ltd.

Contact:86-0512-63197058

Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
Jiangxi Province Bethel Pharmaceutical Co., Ltd.

Contact:+86-795-259 3456 ，+86-15957688008 13566650571

Address:Huangjindui Chemical Park， Shanggao County ，Yichun city，Jiangxi Province
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china

Relevant to this article

From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-α-mannosidase

Doi:10.1021/acs.orglett.8b03260
(2018)
Phenolic constituents from Brainea insignis

Doi:10.1248/cpb.58.868
(2010)
Highly Regioselective Isomerizing Hydroformylation of Long-Chain Internal Olefins Catalyzed by a Rhodium Bis(Phosphite) Complex

Doi:10.1002/cctc.201500743
(2015)
ACTIVATION OF REDUCING AGENTS. SODIUM HYDRIDE CONTAINING COMPLEX REDUCING AGENTS XIX. HOMO COUPLING OF ARYL AND VINYL HALIDES PROMOTED BY LIGAND MODIFIED NiCRA (NaH-RONa-Ni(OAc)2)

Doi:10.1016/0022-328X(84)85152-9
(1984)
One-step RhCl₃-catalyzed deprotection of acyclic N-allyl amides

Doi:10.1021/jo070553t
(2007)
Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity

Doi:10.1021/acs.jmedchem.0c02150
(2021)

Article Doi