Effect of the linking position of a side chain in bis(quinolylmethyl)ethylenediamine as a DNA binding agent

DOI: 10.1248/cpb.48.477

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 477 - 479 (2000)

Update date:2022-08-24

Topics:

Authors:

Mikata, Yuji

Onchi, Yoko

Kishigami, Maki

Yano, Shigenobu

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Article abstract of DOI:10.1248/cpb.48.477

Two bisquinoline derivatives, N,N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N,N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay. These compounds exhibited apparent AT- specificity suggesting minor groove binding in addition to intercalation.

Full text of DOI:10.1248/cpb.48.477

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