Journal of Medicinal Chemistry p. 1248 - 1251 (1980)
Update date:2022-08-16
Topics:
Kim
Dietrich
Hansch
Dolnick
Bertino
Inhibition of dihydrofolate reductase from bovine liver and murine L5178YR-C3 tumor cells has been examined for a series of 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2-X-phenyl)s-triazines. For both enzymes all 2-X substituents cause a decrease i
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