Tetrahedron p. 1593 - 1598 (1980)
Update date:2022-07-31
Topics:
Cherest
The addition of allyl and butenyl Grignard reagents to 4-t-butylcyclohexanone affords a greater proportion of the equatorial alcohols than is formed from the corresponding saturated Grignard reagents (propyl and s-butyl). In the case of the allyl Grignard reagent, the equatorial alcohol is the major product. Lithium aluminium hydride reduction in ether at 0° of cis and trans 4-t-butyl-2-methyl-cyclohexanone and cis and trans 4-t-butyl-2-chlorocyclohexanone affords mixtures of epimeric alcohols in ratios of equatorial to axial OH 8.4:1, 20:1, 4.2:1, and >70:1 respectively. These results fit in well with the view that polar interactions and torsional strain are both important in determining the steric course of the reaction.
Wuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Winchem Industrial Co. Ltd.(expird)
Contact:86-574-83851061 86-574-87083208
Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
LinHai Cina Chemical Co., LTD.
Contact:0576-85580989
Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Fujian Wanke Pharmaceutical Co., LTD.
Contact:+86-598-5026002
Address:Economic development zone,jiangle county
zhejiang huangyan wanfeng pharm chem co.ltd
Contact:+86-576- 84160728
Address:No. 5 Dazha Road, Economic,Development Zone(JiangKou), Zhejiang, China
Doi:10.1016/j.tet.2004.06.019
(2004)Doi:10.1016/S0040-4039(00)78661-8
(1980)Doi:10.1039/c39800000746
(1980)Doi:10.1016/j.tetlet.2004.06.081
(2004)Doi:10.1142/S1088424610001842
(2010)Doi:10.1016/j.bmc.2019.07.030
(2019)
