A New Type of Safety-catch Linker cleaved by Intramolecular Activation of an Amide Anchorage and allowing Aqueous Processing in Solid-phase Peptide Synthesis

DOI: 10.1039/c39930001786

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1786 - 1788 (1993)

Update date:2022-08-30

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Authors:

Sola, Regine

Saguer, Philippe

David, Marie-Laure

Pascal, Robert

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Article abstract of DOI:10.1039/c39930001786

The N³-phenyloxycarbonyl-L-2,3-diaminopropionic acid residue behaves as a versatile linker displaying high stability under neutral and acidic conditions but undergoes activation under mild alkaline conditions for the release of peptide acids or amides by nucleophilic cleavage.

Full text of DOI:10.1039/c39930001786

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