Synthesis p. 427 - 429 (1986)
Update date:2022-08-30
Topics:
Teague, Simon J.
Roth, Gregory P.
Condensation of the α-lithio derivative of 3-substituted 4,4-dialkoxybutanoates, butanenitriles, and butanamides with methoxy-activated aromatic aldehydes, followed by treatment with refluxing dilute sulfuric acid gives rise to substituted naphthalene products.In this manner, 2,6,7-tri- and 2,3,6,7-tetrasubstituted naphthalenes are synthesized in high yields on a multigram scale.
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(1982)
