The Synthesis of Highly Functionalized Naphthalene Derivatives

Article abstract of DOI:10.1055/s-1986-31667

Condensation of the α-lithio derivative of 3-substituted 4,4-dialkoxybutanoates, butanenitriles, and butanamides with methoxy-activated aromatic aldehydes, followed by treatment with refluxing dilute sulfuric acid gives rise to substituted naphthalene products.In this manner, 2,6,7-tri- and 2,3,6,7-tetrasubstituted naphthalenes are synthesized in high yields on a multigram scale.