An efficient stereoselective synthesis of 6-α-aminoestradiol: Preparation of estradiol fluorescent probes

Article abstract of DOI:10.1016/S0039-128X(97)00015-9

6-Oxoestradiol (2) was protected as its bis[(2- trimethylsilylethoxy)methyl] ether (4) and converted to the corresponding oxime (4). The oxime (4) on reduction with zinc in ethanol afforded the bis- SEM ether of 6-α-aminoestradiol (5) in 96% epimeric exce