Journal of labelled compounds and radiopharmaceuticals p. 983 - 991 (1998)
Update date:2022-08-22
Topics:
Lodwig, Siegfried N.
Unkefer, Clifford J.
We have developed a stereoselective route to the synthesis of stable isotope-labeled L-proline. Alkylation of (2R)-N-{N'-[bis(methylthio)methylidine]glycyl}bornane-10,2-sultam with 3-chloro-iodopropane yielded (2R)-N-{(2'S)-2'-{[Bis(methylthio)methylidine]amino}5-chloropentan-1 -oyl}bornane-10,2-sultam. Cyclization to the imino acid occurred during the sequential removal of the α-amino protecting group and the chiral auxiliary.
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