Chemical Communications p. 2213 - 2214 (1996)
Update date:2022-08-10
Topics:
Wu, Wen-Min
Yao, Zhu-Jun
Wu, Yu-Lin
Jiang, Kun
Wang, Yan-Fang
Chen, Hai-Bao
Shan, Feng
Li, Ying
In the presence of iron(II) the peroxy bridge of the drug qinghaosu and its derivatives are cleaved to give two major rearrangement products; DNA damage due to this free radical process is observed and may be responsible for the antimalarial activity of these compounds.
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