Synthesis and antiviral and cytostatic evaluations of the new c-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4′,5′-didehydro-L- ascorbic acid derivatives

Article abstract of DOI:10.1021/jm070324z

The novel C-5 alkynyl substituted pyrimidine (1-11) and furo[2,3-d]pyrimidine derivatives (12-22) of L-ascorbic acid were synthesized by coupling of 5-iodouracil-4′,5′-didehydro-5′,6′-dideoxy- L-ascorbic acid with terminal alkynes by using Sonogashira cro