10.1002/anie.202003807
Angewandte Chemie International Edition
COMMUNICATION
fit into the void spaces of 1S. On the contrary, 1R sheets uptake
exclusively D-form in the racemic tartrate solution, demonstrating
that the enantioselective absorption of the sheets in a racemic
mixture solution arises from the chirality of the sheet (Figure 4d). To
evaluate enantioselectivity of the sheets with different guests, we
carried out the same experiments of 1S with hydrophobically-
substituted phenylalanine (G2).
In conclusion, we have constructed single-layered chiral sheet
structures in aqueous MeOH solution using self-assembly of a
rectangular plate-shaped aromatic amphiphile. The 2-D chiral sheets
consist of lateral arrangement of chiral aromatic clusters with in-
plane up and down AB order, generating dual chiral void spaces in a
hydrophilic solvent. The nanosheets with chiral void spaces function
as superfast enantiomer separation nanomaterials which absorb
rapidly a single enantiomer in a racemic mixture with enantiomeric
excess (ee) greater than 99 %. We anticipate that our strategy to
construct 2-D chiral materials will provides access to porous 2-
dimensional materials with complex functions capable of performing
multiple separations and multiple chemical reactions.
Acknowledgements
This work was supported by the National Natural Science
Foundation of China (21634005 and 51473062) and Fudan
Research Fund.
Keywords: supramolecular assembly • chiral nanosheet • dual
chiral domains • enantiomer absorption
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