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Z.-L. Cheng, Q.-Y. Chen / Journal of Fluorine Chemistry 126 (2005) 93–97
3.1. Typical procedure for Sonogashira coupling reaction
3ca: Solid, IR (film) (cmꢀ1) 2201, 1762, 1598, 1521,
1
1442, 1344, 1272. H NMR (CDCl3) d 8.36–8.40 (m, 2H),
Under nitrogen atmosphere, in a 10 ml side-armed Pyrex
tube with a magnetic stirring bar was placed 1-iodo-3,3-
difluorocyclopropene (1a) (278 mg, 1 mmol), phenylacety-
lene (0.13 ml, 1.2 equiv.), Ag2CO3 (414 mg, 1.5 equiv.) and
THF (5 ml). After frozened by dry ice–ethanol bath,
PdCl2(PPh3)2 (35 mg, 5 mol%) and CuI (19 mg,
10 mol%) were added. The mixture was degassed and
slowly warmed to room temperature and stirred for 8 h. The
reaction mixture was filtered and solvent was removed under
reduced pressure. The residue was purified by flash
chromatography on a silica gel column to give the cross-
coupling compound (3aa) (177 mg, yield 70%).
7.88–7.92 (m, 2H), 7.60–7.66 (m, 2H), 7.40–7.49 (m, 3H).
19F NMR (CDCl3) d ꢀ107.10 (s, 2F). MS m/z (relative
intensity) 297 (M+, 100), 251 (96.95), 247 (25.90), 200
(99.48), 100 (17.46). Anal. Calcd. for C17H9F2NO2: C,
68.69, H, 3.05, N, 4.71, F, 12.07. Found: C, 68.66, H, 3.06,
N, 4.54, F, 12.78. mp 140–142 8C.
3cd: Solid, IR (film) (cmꢀ1) 2959, 2935, 2864, 2228,
1
1768, 1602, 1526, 1467, 1426. H NMR (CDCl3) d 8.33–
8.37 (m, 2H), 7.80–7.84 (m, 2H), 2.57 (t, J = 7.5 Hz, 2H),
1.66–1.71 (m, 2H), 1.37–1.48 (m, 4H), 0.95 (t, J = 6.9 Hz,
3H). 19F NMR (CDCl3) d ꢀ107.24 (s, 2F). MS m/z (relative
intensity) 276 (M+ ꢀ 15, 4.45), 235 (100), 201 (52.80), 188
(63.39), 82 (58.07). Anal. Calcd. for C16H15F2NO2: C,
65.97, H,5.19, N, 4.81, F, 13.04. Found: C, 65.96, H, 5.20, N,
4.43, F, 12.91.
3da: Solid, 1H NMR (CDCl3) d 7.65–7.59 (m, 4H), 7.45–
7.41 (m, 3H), 7.30–7.34 (m, 2H), 2.45 (s, 3H). 19F NMR
(CDCl3) d ꢀ106.72 (s, 2F). MS m/z (relative intensity) 266
(M+, 100), 251 (M+ ꢀ 15, 92.65). Anal. Calcd. for C18H12F2:
C, 81.19, H, 4.54, F, 14.27. Found: C, 81.20, H, 4.41, F,
13.79.
3aa: Solid, 1H NMR (CDCl3) d 7.73–7.77 (m, 2H), 7.60–
7.63 (m, 2H), 7.51–7.54 (m, 3H), 7.40–7.47 (m, 3H). 19F
NMR (CDCl3)d ꢀ107.04 (s, 2F). MS m/z (relative intensity)
252 (M+, 100), 251 (M+ ꢀ 1, 93.75), 233 (22.64), 202
(61.19), 175 (6.38), 150 (6.47), 101 (2.15). Anal. Calcd. for
C17H10F2: C, 80.94, H, 4.00, F, 15.06. Found: C, 80.63, H,
4.24, F, 15.23.
3ab: Solid, IR (film) (cmꢀ1) 2203, 1763, 1597, 1583,
1
1494, 1482, 1465, 1449, 1270. H NMR (CDCl3) d 7.72–
7.77 (m, 2H), 7.45–7.58 (m, 7H). 19F NMR (CDCl3) d
ꢀ106.92 (s, 2F). MS m/z (relative intensity) 332 (M+ + 2,
4.41), 330 (M+, 4.68), 251 (48.88), 200 (100), 174 (29.14),
100 (34.19). Anal. Calcd. for C17H9BrF2: C, 61.66, H, 2.74,
F, 11.47. Found: C, 61.58, H, 3.00, F, 11.40. mp100–102 8C.
3ac: Solid, 1H NMR (CDCl3, 300 MHz) d 7.71–7.75 (m,
3ea: Solid, 1H NMR (CDCl3) d 7.71–7.41 (m, 7H), 7.04–
7.01 (m, 2H), 3.90 (s, 3H). 19F NMR (CDCl3) d ꢀ106.99 (s,
2F). MS m/z (relative intensity) 282 (M+, 100), 267
(M+ ꢀ 15, 39.98), 251 (M+ ꢀ 31, 23.42), 238 (66.45), 189
(71.30). HRMS Calcd. for C18H12F2O: 282.0856. Found:
282.0831.
3fa: Liquid, 1H NMR (CDCl3) d 7.60–7.36 (m, 5H), 2.61
(m, 2H), 1.72 (t, J = 7.2 Hz, 2H), 1.48–1.38 (m, 4H), 0.96 (t,
J = 7.2 Hz, 3H). 19F NMR (CDCl3) d ꢀ102.63 (s, 2F). MS
m/z (relative intensity) 246 (M+, 7.50), 231 (M+ ꢀ 15,
20.92), 203 (64.13), 139 (100). HRMS Calcd. for C16H16F2:
246.1220. Found: 246.1205.
2H), 7.48-7.53 (m, 5H), 7.21–7.24 (m, 2H), 2.41 (s, 3H). 19
F
NMR (CDCl3) d ꢀ107.36 (s, 2F). MS m/z (relative intensity)
266 (M+, 100), 251 (M+ ꢀ 15, 85.95). Anal. Calcd. for
C18H12F2: C, 81.19, H, 4.54, F, 14.27. Found: C, 81.23, H,
4.46, F, 14.15.
3ad: Liquid, IR (film) (cmꢀ1) 2960, 2935, 2231, 1772,
1494, 1467, 1451, 1268. 1H NMR (CDCl3) d 7.65–7.70 (m,
2H), 7.47–7.50 (m, 3H), 2.54 (t, J = 7.2 Hz, 2H), 1.64–1.70
(m, 2H), 1.37–1.49 (m, 4H), 0.95 (t, J = 6.9 Hz, 3H). 19F
NMR (CDCl3) d ꢀ107.25 (s, 2F). MS m/z (relative intensity)
246 (M+, 12.56), 190 (100), 183 (70.29), 164 (61.78), 139
(56.44). HRMS for C16H16F2: 246.1220. Found: 246.1220.
3ba: Solid, IR (film) (cmꢀ1) 2202, 1767, 1584, 1494,
3.2. Difluorocarbene addition to 3
Under nitrogen atmosphere in a Schlenk tube with a
stirring bar was placed 3aa (150 mg, 0.6 smmol), NaF
(2.5 mg, 0.06 mmol), and DG (1 ml). At the temperature of
120 8C TFDA (450 mg, 1.8 mmol) was added dropwise via a
syringe. The mixture was stirred for 2 h at this temperature.
Then the mixture was cooled to room temperature and
directly purified by flash chromatography on a silica gel
column. 3aa (35 mg) was recycled and 4aa (112 mg) was
obtained as white solid.
1
1481, 1445, 1258. H NMR (CDCl3) d 7.57–7.69 (m, 6H),
7.40–7.48 (m, 3H). 19F NMR (CDCl3) d ꢀ107.11 (s, 2F). MS
m/z (relative intensity) 332 (M+ + 2, 24.84), 330 (M+, 25.48),
282 (20.85), 280 (21.32), 251 (100), 200 (37.00). Anal.
Calcd. for C17H9BrF2: C, 61.66, H, 2.74, F, 1.47. Found: C,
61.58, H, 3.00, F, 11.40.
4aa: Solid, 1H NMR (CDCl3) d 7.54–7.60 (m, 6H), 7.77–
7.80 (m, 4H). 19F NMR (CDCl3) d ꢀ109.1. MS m/z (relative
intensity) 302 (M+, 97.06), 282 (20.66), 262 (6.33), 251
(100.00), 233 (21.140), 202 (25.07), 151 (10.09). Anal.
Calcd. for C18H10F4: C, 71.52; H, 3.33; F, 25.14. Found: C,
71.44; H, 3.32; F, 25.22.
3bd: Liquid, IR (film) (cmꢀ1) 2959, 2935, 2231, 1772,
1
1587, 1488, 1467, 1356, 1280. H NMR (CDCl3) d 7.60–
7.65 (m, 2H), 7.50–7.55 (m, 2H), 2.53 (t, J = 7.5 Hz, 2H),
1.63–1.69 (m, 2H), 1.36–1.48 (m, 4H), 0.95 (t, J = 6.9 Hz,
3H). 19F NMR (CDCl3) d ꢀ107.25 (s, 2F). MS m/z (relative
intensity) 326 (M+ + 2, 11.19), 324 (M+, 11.87), 270 (66.44),
268 (70.38), 201 (69.33), 188 (100), 183 (45.59). HRMS
Calcd. for C16H15BrF2: 324.0325. Found: 324.0311.
4ba: Solid, IR (film) (cmꢀ1) 1723, 1585, 1483, 1450,
1
1307, 1280, 1243. H NMR (CDCl3) d 7.79–7.54 (m, 9H).
19F NMR (CDCl3) d ꢀ109.50 (s, 4F). MS m/z (relative