H/D Exchange Reaction between CHCl3 and D2O in Two-Liquid-Phase System

Article abstract of DOI:10.1021/j100350a023

The kinetics of hydrogen isotope exchange between CHCl3 and D2O has been studied by using a system which is composed of two liquid phases, a chloroform phase and an aqueous phase.The area of the interface between these two phases was kept constant (5.7 x 10^-3 m²) during the reaction, where the reaction may be controlled by the interfacial transfer of chloroform.The isotopic content of chloroform in the chloroform phase was determined by an infrared absorption measurement.After the reaction, disappearance of deuteroxide ion was observed, which is caused by the chloroform hydrolysis reaction.The experimental results are reasonably explained on the basis of the model in which the reaction process is assumed to be composed of two steps: interfacial transfer of chloroform from the chloroform phase to the aqueous phase or vice versa, and the hydrogen isotope exchange reaction between CHCl3 and D2O in the aqueous phase.The rate constants for the interfacial transfer of chloroform and for the exchange reaction in the aqueous phase at 26.0 deg C were 0.107 +/- 0.003 m^-2s^-1 and 0.231 +/- 0.013 Lmol^-1s^-1, respectively.