Stereoselective synthesis of the chiral tetrahydropyrane core of swinholides and misakinolides

Article abstract of DOI:10.1246/cl.1999.601

Stereoselective synthesis of the optically pure tetrahydropyrane core of swinholides and misakinolide A starting from (S)-methyl lactate is described in which the highly stereoselective intramolecular iodoetherification for construction of the tetrahydropyrane ring and the regioselective ring-opening reaction of an epoxide are involved as key steps.