First Electrophilic Substitution of 4-Methoxyindole with Triethyl Orthoformate as an a1-Synthon

DOI: 10.1007/BF00810297

Source and publish data:

Monatshefte fur Chemie p. 77 - 80 (1990)

Update date:2022-08-29

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Authors:

Pindur, Ulf

Witzel, Helmut

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Article abstract of DOI:10.1007/BF00810297

4-Methoxyindole (2) reacts with triethyl orthoformate (1a) under proton catalysis to yield the functionalized indoles 3a - 3e in dependence on the reaction conditions.The attack of the electrophile takes place regiospecifically at the 3-position of the indole 2.

Full text of DOI:10.1007/BF00810297

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