Research on heterocyclic compounds. XXXI. Synthesis and antiinflammatory activity of 2-arylimidazopyrazine-3-carboxylic acids

Article abstract of DOI:10.1016/0223-5234(93)90150-D

The sythesis of a series of 2-phenyl- and 2-(p-chlorophenyl)imidazo<1,2-a>pyrazine-3-carboxylic esters and acids is described.The structures of the new compounds were supported by 1H- and 13C-NMR spectra.These compounds were evaluated in vivo for their antiinflammatory and analgesic activities as well as for their ulcerogenic potential.Acids 8c and 8e were found to be the most potent antiinflammatory agents (ca. 1/8 x indomethacin), while 8a, 8d and 8f displayed analgesic activity (ca. 1/16 x indomethacin).The inhibitory activity on cyclooxygenase action was evaluated in vitro and discussed in comparison with results obtained in vivo. imidazo<1,2-a>pyrazines / antiinflammatory activity / analgesic activity / ulcerogenic activity / cyclooxygenase inhibition