Preparation and use of tritiated Schwartz' reagent (ZrCp2Cl3H)

Article abstract of DOI:10.1080/00397919408020780

Treatment of Li³H with ZrCp₂Cl₂ in THF affords ZrCp₂Cl³H. By the action of ZrCp₂Cl³H on an acetylene, it is possible to stereo- and regioselectively introduce tritium into the vinylic position, a site which has often proved to be metabolically stable in complex molecules. In addition, ZrCp₂Cl³H may be used to regioselectively label olefins with tritium.

Full text of DOI:10.1080/00397919408020780

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Preparation and Use of
Tritiated Schwartz' Reagent
3
(
ZrCp Cl H)
2
a b
b
a
E. M. Zippi
, H. Andres , H. Morimoto & P. G.
a
Williams
a
National Tritium Labeling Facility, Structural
Biology Division , Lawrence Berkeley Laboratory ,
Berkeley, CA, 94720, U.S.A.
b
Sandoz Pharma Ltd, Chemical Research and
Development , Basle, CH-4002, Switzerland
Published online: 23 Sep 2006.
To cite this article: E. M. Zippi , H. Andres , H. Morimoto & P. G. Williams
3
(
1994) Preparation and Use of Tritiated Schwartz' Reagent (ZrCp Cl H), Synthetic
2
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 24:7, 1037-1044, DOI: 10.1080/00397919408020780
To link to this article: http://dx.doi.org/10.1080/00397919408020780
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