D. Ye et al. / Tetrahedron Letters 48 (2007) 4023–4027
4027
as neuraminidase inhibitors for anti-H5N1 subtype of
avian influenza virus (AIV). A plausible reaction mech-
anism involving the formation of the oxazolinium inter-
mediate was provided. Further studies will be developed
to elucidate the scope and limitation of this reaction,
and will be reported in due course.
kov, Y. E.; Schmidt, R. R. Tetrahedron Lett. 1997, 38,
837–6840.
. Murakami, M.; Ikeda, K.; Achiwa, K. Carbohydr. Res.
996, 280, 101–110.
. Honda, T.; Masuda, T.; Yoshida, S.; Arai, M.; Kobay-
ashi, Y.; Yamashita, M. Bioorg. Med. Chem. Lett. 2002,
6
8
9
1
1
2, 1921–1924.
1
0. Li, J.; Zheng, M. Y.; Tang, W.; He, P. L.; Zhu, W. L.; Li,
T. X.; Zuo, J. P.; Liu, H.; Jiang, H. L. Bioorg. Med. Chem.
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Acknowledgments
1
1. X-ray crystallographic data of 2a were solutions at
We gratefully acknowledge generous support from the
National Natural Science Foundation of China (Grants
34 2 r
T = 273(2) K: C22H N O12, M = 518.51, monoclinic,
space group P2 (1), a = 12.069(2) A, b = 10.4513(19) A,
˚
˚
˚
c = 21.177(4) A, a = 90ꢁ, b = 103.400(4)ꢁ, c = 90ꢁ, V =
2
0372069, 29725203 and 20472094), the Key Tech-
nologies R&D Program from CAS (Grants
005BA711A01), and the 863 Hi-Tech Program of
˚
3
3
2
598.5(8) A , Z = 4, D
X
= 1.325 mg/m , F(000) = 1104,
˚
À1
k(MoKa) = 0.71073 A, l = 0.108 mm . CCDC 633149
contains the supplementary crystallographic data for this
2
China (Grants 2006AA020402, 2006AA020602).
References and notes
1
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1
2
4
14. General process for the synthesis of 2a–i: 100 mg
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the solvent was evaporated under vacuum below 40 ꢁC,
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acetate, then washed with water (10 mL · 3) and dried
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chromatography with silica gel.
3
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7
1