SELECTIVE ELECTROPHILIC MONOFLUORINATION ON RINGS OF VARIOUS SIZES USING ELEMENTAL FLUORINE

Article abstract of DOI:10.1016/S0022-1139(00)84983-0

Elemental fluorine substitutes tertiary unactivated hydrogens in an electrophilic mode.This unorthodox substitution depends on the atomic charge density, on the hydrogen atom and on the p-orbital contribution on the C-H bond.This is demonstrated by reacti