Journal of Pharmaceutical Sciences p. 90 - 92 (1983)
Update date:2022-08-11
Topics:
Guilarte
Burns
Dannals
Wagner Jr.
A radiometric method for screening acetylcholinesterase inhibitors has been described. The method is based on the production of [14C]carbon dioxide from the hydrolysis of acetylcholine. The inhibitory concentration at 50% (IC50) values for several known acetylcholinesterase inhibitors were in agreement with literature values. The new radiometric method is simple, inexpensive, and has the potential for automation.
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