Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Glyburide

Related Products

Hot Products

Name

Glyburide

EINECS 233-570-6
CAS No. 10238-21-8 Density 1.36 g/cm3
PSA 121.98000 LogP 5.89520
Solubility Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96%) and in methanol. Practically insoluble in ether. It dissolves in dilute solutions of alkali hydroxides. Melting Point 173-175 °C
Formula C23H28 Cl N3 O5 S Boiling Point N/A
Molecular Weight 494.011 Flash Point N/A
Transport Information N/A Appearance white or almost white crystalline podwer
Safety 22-36/37/39 Risk Codes 20/21/22
Molecular Structure Molecular Structure of 10238-21-8 (Glibenclamide) Hazard Symbols Xn
Synonyms

Urea,1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexyl- (8CI);1-[4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl]-3-cyclohexylurea;Adiab;Antibet;Apo-Glibenclamide;Betanaz;Betanese 5;Calabren;Cytagon;Daonil;Daonil N;Debtan;Dia-basan;Diabeta;Diabiphage;Dibelet;Duraglucon;Euglucan;Euglucon;Euglucon 5;Euglykon;GBN 5;Gilemal;Gl;Glamide;Gliban;Gliben;Gliben-Puren N;Glibenclamide;Glibenil;Glibens;Glibesyn;Glibet;Glibetic;Glibil;Glibomet;Gliboral;Glicem;Glidiabet;Glucobene;Glucohexal;Glucolon;Glucomid;Glucoremed;Glucoven;Glukovital;Glyben;Glybenzcyclamide;Glycomin;HD 419;Hemi-Daonil;Libanil;Melix;N-4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl-N'-cyclohexylurea;N-[4-[b-(2-Methoxy-5-chlorobenzamido)ethyl]benzenesulfonyl]-N'-cyclohexylurea;Orabetic;Pira;Prodiabet;Renabetic;Semi-Daonil;

Article Data 26

Glyburide Synthetic route

16673-34-0

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide

3173-53-3

Cyclohexyl isocyanate

10238-21-8

Glibenclamid

Conditions
ConditionsYield
With copper(l) chloride In nitromethane at 20℃; for 2h; Reagent/catalyst; Solvent; Concentration; Milling;100 %Spectr.
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 0.166667h; Sealed tube;81 mg
With 18-crown-6 ether; potassium tert-butylate In N,N-dimethyl-formamide at 0 - 5℃; for 6h; Reflux;4.49 g
201230-82-2

carbon monoxide

4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl azide

108-91-8

cyclohexylamine

10238-21-8

Glibenclamid

Conditions
ConditionsYield
With palladium diacetate In acetonitrile at 20℃; under 15 Torr; Schlenk technique; Sealed tube;99%

C19H21ClN2O6S*C6H13N

10238-21-8

Glibenclamid

Conditions
ConditionsYield
In toluene at 110℃; Industrial scale;
3438-16-2

5-chloro-2-methoxybenzoic acid

10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl dichloride / dichloromethane / 12 h / 20 °C / Schlenk technique
2: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
3: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 5 steps
1: oxalyl dichloride / dichloromethane / 12 h / 20 °C / Schlenk technique
2: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
3: chlorosulfonic acid / 1,2-dichloro-ethane / 50 °C / Schlenk technique
4: sodium azide / acetonitrile / 50 °C / Schlenk technique
5: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 4 steps
1: phosphorus trichloride / tetrahydrofuran / 0.08 h / 150 °C / Sealed tube
2: chlorosulfonic acid / chloroform / 0.17 h / 60 °C / Sealed tube
3: ammonium hydroxide / 1,4-dioxane / 0.17 h / 120 °C / Sealed tube; Cooling with ice
4: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
View Scheme
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 1,2-dichloro-ethane / 50 °C / Schlenk technique
2: sodium azide / acetonitrile / 50 °C / Schlenk technique
3: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 3 steps
1: chlorosulfonic acid / chloroform / 0.17 h / 60 °C / Sealed tube
2: ammonium hydroxide / 1,4-dioxane / 0.17 h / 120 °C / Sealed tube; Cooling with ice
3: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
View Scheme
64-04-0

phenethylamine

10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: phosphorus trichloride / tetrahydrofuran / 0.08 h / 150 °C / Sealed tube
2: chlorosulfonic acid / chloroform / 0.17 h / 60 °C / Sealed tube
3: ammonium hydroxide / 1,4-dioxane / 0.17 h / 120 °C / Sealed tube; Cooling with ice
4: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / tetrahydrofuran / 4 h / 20 °C / Cooling with ice
2.1: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice
3.1: ammonium hydroxide / acetone / 20 °C
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: potassium tert-butylate; 18-crown-6 ether / N,N-dimethyl-formamide / 6 h / 0 - 5 °C / Reflux
View Scheme
29568-33-0

2-methoxy-5-chlorobenzoyl chloride

10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
2: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
2: chlorosulfonic acid / 1,2-dichloro-ethane / 50 °C / Schlenk technique
3: sodium azide / acetonitrile / 50 °C / Schlenk technique
4: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
33924-54-8

4-(2-[(5-chloro-2-methoxyphenyl)formamido]ethyl)benzene-1-sulfonyl chloride

10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide / acetonitrile / 50 °C / Schlenk technique
2: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
16673-34-0

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide

10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonium hydroxide / acetone / Industrial scale
2.1: pyrographite / acetone / 1.17 h / Reflux; Industrial scale
2.2: 0.5 h / 58 °C / Industrial scale
3.1: toluene / 110 °C / Industrial scale
View Scheme
458-85-5

2,2,2-trifluoro-N-(2-phenylethyl)acetamide

10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice
2.1: ammonium hydroxide / acetone / 20 °C
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: potassium tert-butylate; 18-crown-6 ether / N,N-dimethyl-formamide / 6 h / 0 - 5 °C / Reflux
View Scheme

Glyburide Specification

The Glyburide has the cas register number 10238-21-8, and it is a kind of white crystalline powder. The IUPAC name and systematic name are the same which is 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide. This chemical is insoluble in water while slightly soluble in ethanol, acetone, chloroform, and its product categories are including Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Organics; Amino Acids & Derivatis; Isotope Labeled Compounds; API's; Potassium channel; Ion Channels. When you neee to store it, keep it in a dry, cool and well-ventilated storeroom.

The physical properties of this chemical are as follows: (1)ACD/LogP: 3.75; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.58; (4)ACD/LogD (pH 7.4): 1.79; (5)ACD/BCF (pH 5.5): 27.82; (6)ACD/BCF (pH 7.4): 4.52; (7)ACD/KOC (pH 5.5): 173.93; (8)ACD/KOC (pH 7.4): 28.24; (9)#H bond acceptors: 8; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 95.61; (13)Index of Refraction: 1.616; (14)Molar Refractivity: 126.9 cm3; (15)Molar Volume: 362.9 cm3; (16)Polarizability: 50.3×10-24 cm3; (17)Surface Tension: 61.2 dyne/cm; (18)Density: 1.36 g/cm3; (19)Exact Mass: 493.143819; (20)MonoIsotopic Mass: 493.143819; (21)Topological Polar Surface Area: 122; (22)Heavy Atom Count: 33; (23)Formal Charge: 0; (24)Complexity: 746.

As to its usage, it is usually applied in pharmaceutics. It could be used as the hypoglycemicagent, with better curative effect than tolbutamide; It is often used in the curing of mild and moderate non-insulin-dependent diabetes mellitus.

When you are dealing with this kind of chemical, you should be much more careful and then take some measures to protect yourself. Being a kind of harmful chemical, it may cause damage to health. And if by inhalation, in contact with skin and if swallowed, you will be hurt by this chemical. Therefore, you should take the following instructions. Wear suitable protective clothing, gloves and eye/face protection while using and then do not breathe dust.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
(2)InChI: InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-
10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
(3)InChIKey: ZNNLBTZKUZBEKO-UHFFFAOYSA-N 

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1404, 1969.
 
guinea pig LD50 oral > 15gm/kg (15000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1404, 1969.
 
man TDLo oral 209mg/kg/4Y-I (209mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: "JAUNDICE, CHOLESTATIC"

LIVER: OTHER CHANGES
Western Journal of Medicine. Vol. 168, Pg. 274, 1998.
 
mouse LD50 intraperitoneal 2700mg/kg (2700mg/kg)   Pharmaceutical Chemistry Journal Vol. 29, Pg. 265, 1995.
mouse LD50 oral 3250mg/kg (3250mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1640, 1966.
 
mouse LD50 subcutaneous > 20gm/kg (20000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 247, 1970.
rabbit LD oral > 20gm/kg (20000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 247, 1970.
rat LD50 intraperitoneal 3750mg/kg (3750mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1413, 1969.
 
rat LD50 oral > 20gm/kg (20000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1413, 1969.
 
rat LD50 subcutaneous > 20gm/kg (20000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1413, 1969.
 
women TDLo oral 147ug/kg (0.147mg/kg) BEHAVIORAL: COMA

ENDOCRINE: HYPOGLYCEMIA
Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 142, 1984.
 

 

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 10238-21-8