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Glycinamide Hydrochloride

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Name

Glycinamide Hydrochloride

EINECS 216-789-1
CAS No. 1668-10-6 Density 1.122 g/cm3
PSA 69.11000 LogP 0.63300
Solubility water: 0.1 g/mL, clear Melting Point 204 °C (dec.)(lit.)
Formula C2H6N2O.HCl Boiling Point 281.3 °C at 760 mmHg
Molecular Weight 110.54 Flash Point 123.9 °C
Transport Information Appearance Crystalline
Safety 26-37/39 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 1668-10-6 (Acetamide, 2-amino-,hydrochloride (1:1)) Hazard Symbols IrritantXi
Synonyms

Acetamide,2-amino-, monohydrochloride (9CI);Glycinamide, monohydrochloride (8CI);Aminoacetamide hydrochloride;Glycine amide hydrochloride;H-Gly-NH2·HCl;H-Gly-NH2.HCl;

 

Glycinamide Hydrochloride Synthetic route

540-61-4

2-aminoacetonitrile

1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; 2-hydroxyethanethiol In tetrahydrofuran at -78℃;86%
79-07-2

Chloroacetamide

1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
With ammonia In ethanol at 100℃; for 0.5h;76%
141509-41-3

4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione

A

1668-10-6

glycinamide hydrochloride

B

114533-59-4

3-hydroxy-4-(2-hydroxyethyl)-2(5H)-furanone

Conditions
ConditionsYield
With hydrogenchloride at 100℃; for 1.5h; Product distribution; other conditions, other reagents;A 33%
B 56%

2-amino-acetimidic acid methyl ester; dihydrochloride

1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
bei dreiwoechigem Aufbewahren;
5680-79-5

glycine ethyl ester hydrochloride

1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
With ammonia In methanol for 72h; Ambient temperature;
1668-10-6

glycinamide hydrochloride

1148-11-4

N-Benzyloxycarbonyl-L-proline

35010-96-9

Nα-benzyloxycarbonyl-L-prolyl-glycinamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;100%
Stage #1: N-Benzyloxycarbonyl-L-proline With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃;
Stage #2: glycinamide hydrochloride With triethylamine In tetrahydrofuran at 20℃; Further stages.;
53%
With 4-methyl-morpholine; isobutyl chloroformate 1) DMF, -15 deg C, 15 min, 2) -10 deg C, 14h; Yield given. Multistep reaction;
1668-10-6

glycinamide hydrochloride

60379-01-3

N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester

17187-05-2

Z-L-phenylalanylglycinamide

Conditions
ConditionsYield
With S166C-SBnCOOH; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 1h; Ambient temperature;100%
With triethylamine; enzyme mutant SBL-S166C-S-[(4S,5R)-indenooxazolidinonyl] In water; N,N-dimethyl-formamide at 20℃; for 1h; pH=5.8;100%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Glc(Ac)2 subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 1h; pH=5.8; Enzymatic reaction; MES buffer;95%
With subtilisin BPN'; triethylamine In water; N,N-dimethyl-formamide Ambient temperature;80%
5672-83-3

Z-L-GluOMe

1668-10-6

glycinamide hydrochloride

126530-12-9

Z-L-Glu-Gly-NH2

Conditions
ConditionsYield
With S166C-SCH2CH2NH3+; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;100%
With triethylamine; enzyme mutant SBL-S166C-S-CH2C(CH2NH3)3 In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8;71%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Gal subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8; Enzymatic reaction; MES buffer;67%
1668-10-6

glycinamide hydrochloride

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

115057-37-9

Fmoc-Gly-NH2

Conditions
ConditionsYield
With sodium carbonate In acetone at 20℃; for 1h;100%
With sodium hydrogencarbonate In acetone at 20℃; for 2h; pH=7;80%
With sodium carbonate In water; acetone at 0 - 20℃; for 1.5h;72%
912773-22-9

6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

1668-10-6

glycinamide hydrochloride

1065082-89-4

N-(2-amino-2-oxoethyl)-6-bromopyrazolo[1,5-a]pyrimidine-3-carboxamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;100%
1435472-77-7

sodium 1-(2,5-dimethoxyphenyl)-3-ethoxy-3-oxoprop-1-en-1-olate

1668-10-6

glycinamide hydrochloride

1435472-78-8

ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With sodium methylate at 65℃; for 1h;
Stage #2: sodium 1-(2,5-dimethoxyphenyl)-3-ethoxy-3-oxoprop-1-en-1-olate With acetic acid at 10℃; for 16.5h;
100%
1668-10-6

glycinamide hydrochloride

126028-14-6

2,2,2-trifluoroethyl ((benzyloxy)carbonyl)-L-phenylalaninate

A

1161-13-3

N-Cbz-L-Phe

B

17187-05-2

Z-L-phenylalanylglycinamide

Conditions
ConditionsYield
With Tris buffer; TEA; Celite; α-chymotrypsin In acetonitrile at 30℃; for 1h;A 0.6%
B 99%
1668-10-6

glycinamide hydrochloride

69861-90-1

Nα-benzyloxycarbonyl-L-lysine thiobenzyl ester

Z-L-Lys-Gly-NH2

Conditions
ConditionsYield
With S166C-SBnCOOH; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;99%
1668-10-6

glycinamide hydrochloride

88718-12-1

Z-L-Ala benzyl ester

4976-59-4

CBZ-L-alanylglycinamide

Conditions
ConditionsYield
With triethylamine; enzyme mutant SBL-S166C-S-(CH2)2-NMe3(1+) In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8;99%
With S166C-SBn; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;95%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Gal(Ac)3 subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8; Enzymatic reaction; MES buffer;92%
1668-10-6

glycinamide hydrochloride

35899-43-5

Boc-His(Tos)-OH

N-Boc-Nim-tosylhistidylglycinamide

Conditions
ConditionsYield
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran for 24h; slowly from 0 deg C to room temp.;98%
1668-10-6

glycinamide hydrochloride

192214-00-9

(S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid

1352661-21-2

C15H19N3O4

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; for 24h; Inert atmosphere;98%
1668-10-6

glycinamide hydrochloride

113699-68-6

<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>chloride

2-<<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>amino>acetamide

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane for 1h; Ambient temperature;97.8%
1207971-26-3

3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoic acid

1668-10-6

glycinamide hydrochloride

1207965-95-4

N-(2-amino-2-oxoethyl)-3-{4-fluoro-2-[3-(trifluoromethyl)-benzyl]-1-benzothiophen-7-yl}benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 0 - 20℃; for 1h; Inert atmosphere;97%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 5h;60%
1668-10-6

glycinamide hydrochloride

814-68-6

acryloyl chloride

2479-62-1

N-acryloyl glycinamide

Conditions
ConditionsYield
With potassium carbonate In water; acetonitrile at 5 - 30℃; for 7h; Reagent/catalyst; Solvent;97%
Stage #1: glycinamide hydrochloride With potassium carbonate In water
Stage #2: acryloyl chloride In diethyl ether; water at 5 - 20℃;
72%
With potassium carbonate In dichloromethane at 5 - 20℃; pH=7 - 8;68%
585-76-2

m-bromobenzoic acid

1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-3-bromobenzamide

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With triethylamine In dichloromethane for 0.25h;
Stage #2: m-bromobenzoic acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; Cooling with ice;
97%
1668-10-6

glycinamide hydrochloride

71449-08-6

(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid

146349-33-9

D-(benzyloxycarbonyl)-β-tert-butylaspartylglycinamide

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide a) 4 deg C, 3 h, b) RT, 4 h;96.6%
1668-10-6

glycinamide hydrochloride

131949-12-7

(1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl

(1H-indol-3-ylcarbonyl)-Asp(Gly-NH2)-Phe-NMeBzl

Conditions
ConditionsYield
With benzotriazol-1-ol In N,N-dimethyl-formamide 1.) 0 deg C, 1 h, 2.) RT, 3 h;96%
5435-64-3

3,5,5-trimethyl hexanal

1668-10-6

glycinamide hydrochloride

1378479-17-4

(+/-)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one

Conditions
ConditionsYield
With triethylamine In methanol for 18h; Inert atmosphere; Reflux;96%

2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxylic acid

1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;96%
1118-66-7

4-Aminopent-3-en-2-one

1668-10-6

glycinamide hydrochloride

131474-82-3

N-(1-methyl-3-oxo-1-butenyl)glycinamide

Conditions
ConditionsYield
In methanol for 3h; Heating;95%
716-76-7

3-phenylbenzoic acid

1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-[1,1‘-biphenyl]-3-carboxamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane95%
1668-10-6

glycinamide hydrochloride

56-40-6

glycine

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With sodium hydroxide In water
Stage #2: In water at 130℃; for 1h; Reagent/catalyst;
94.5%
1065083-05-7

6-boronopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

1668-10-6

glycinamide hydrochloride

1065083-09-1

(3-{[(2-amino-2-oxoethyl)amino]carbonyl}pyrazolo[1,5-a]pyrimidin-6-yl)boronic acid

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;94%
1207970-84-0

ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate

1668-10-6

glycinamide hydrochloride

1207965-12-5

N-(2-amino-2-oxoethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

Conditions
ConditionsYield
Stage #1: ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate With water; sodium hydroxide In tetrahydrofuran; ethanol at 60℃; for 0.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water
Stage #3: glycinamide hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 2h;
94%
1178896-02-0, 1251932-92-9

2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

1668-10-6

glycinamide hydrochloride

1251933-09-1

2-(3-(2-amino-2-oxoethylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 100℃; for 3h; Microwave irradiation; Sealed vial;94%
110-41-8

2-methylundecanal

1668-10-6

glycinamide hydrochloride

1378479-35-6

(+/-)-2-(undecan-2-yl)imidazolidin-4-one

Conditions
ConditionsYield
With triethylamine In methanol for 18h; Inert atmosphere; Reflux;94%
1668-10-6

glycinamide hydrochloride

Fmoc-Asp(tBu)-Glu(tBu)-Val-Asp(tBu)-OH

C47H66N6O13

Conditions
ConditionsYield
Stage #1: Fmoc-Asp(tBu)-Glu(tBu)-Val-Asp(tBu)-OH With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.75h;
Stage #2: glycinamide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;
94%
1668-10-6

glycinamide hydrochloride

114042-88-5

5-amino-4-hexen-3-one

131474-85-6

N-(1-methyl-3-oxo-1-pentenyl)glycinamide

Conditions
ConditionsYield
In methanol for 3h; Heating;93%
104029-20-1

ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate

1668-10-6

glycinamide hydrochloride

1435472-76-6

(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With sodium methylate In methanol at 65℃; for 1h;
Stage #2: ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate With acetic acid at 50℃; for 16h;
93%
Stage #1: glycinamide hydrochloride With sodium methylate In methanol at 65℃; for 1h;
Stage #2: ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate With acetic acid In methanol at 50℃; for 16h; Reflux;
339.4 g
1668-10-6

glycinamide hydrochloride

131474-81-2

(Z)-3-amino-1-(p-tolyl)but-2-en-1-one

131474-97-0

N-(1-methyl-3-oxo-3-p-tolyl-1-propenyl)glycinamide

Conditions
ConditionsYield
In methanol for 6h; Heating;92%

Glycinamide Hydrochloride Chemical Properties

IUPAC Name: 2-Aminoacetamide hydrochloride
Molecular Formula: C2H7ClN2O
Molecular Weight:110.542780 g/mol
Appearance: White to off-white solid
Water solubility: 0.1 g/mL, clear
BRN: 3554199
Density: 1.122g/cm3
Melting Point: 204 oC
Flash Point: 123.9°C
storage temp.: Store at RT.
Index of Refraction: 1.469
Surface Tension: 49.1 dyne/cm 
Enthalpy of Vaporization: 52.01 kJ/mol
Boiling Point: 281.3 °C at 760 mmHg
Vapour Pressure: 0.00359 mmHg at 25 °C
Synonyms of Glycinamide Hydrochloride(1668-10-6):
h-Gly-nh2 hcl;glycinamide hcl ; Glycinamide hydrochloride ; Glycine-nh2 hcl;glycine amide hydrochloride ; Gly-nh2 hydrochloride ; 2-Aminoacetamide hydrochloride ; Glycinamide monohydrochloride
Categories of Glycinamide Hydrochloride(1668-10-6):
Amino Acid Derivatives;(intermediate of oxiracetam);Amino Acids;Glycine [Gly, G];Amino Acids and Derivatives;Amino hydrochloride;Amides;Carbonyl Compounds;Organic Building Blocks;A - HOrganic Building Blocks;Amino Acids;Modified Amino Acids

Glycinamide Hydrochloride Uses

 Glycinamide Hydrochloride(1668-10-6) is used as a pharmaceutical intermediate,also used in the organic synthesis.

Glycinamide Hydrochloride Safety Profile

Safety Information of Glycinamide Hydrochloride(1668-10-6):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin 
Safety Statements:22-24/25-37/39-26
22:Do not breathe dust
24/25:Avoid contact with skin and eyes 
37/39:Wear suitable gloves and eye/face protection 
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice    
WGK Germany:3
F:3-10
HS Code:29241900

Glycinamide Hydrochloride Specification

First Aid Measures of Glycinamide Hydrochloride(1668-10-6):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Storage of Glycinamide Hydrochloride(1668-10-6):
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

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