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Name |
Hydrocupreine ethyl ether |
EINECS | N/A |
CAS No. | 522-60-1 | Density | 1.18g/cm3 |
PSA | 45.59000 | LogP | 3.72520 |
Solubility | N/A | Melting Point |
123-128° when solvent-free |
Formula | C21H28 N2 O2 | Boiling Point | 508.7°Cat760mmHg |
Molecular Weight | 340.466 | Flash Point | 261.5°C |
Transport Information | N/A | Appearance | N/A |
Safety | Poison by ingestion and subcutaneous routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also ETHERS. | Risk Codes | R22 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
Hydrocinchonidine,6'-ethoxy- (7CI); Hydrocupreine, O6'-ethyl- (8CI); Hydrocupreine, ethyl ether(6CI); Ethylhydrocupreine; Numoquin; Optichin; Optochin |
Article Data | 5 |
ethyl bromide
(8α,9R)-10,11-dihydro-cinchonan-6',9-diol
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
Stage #1: (8α,9R)-10,11-dihydro-cinchonan-6',9-diol With caesium carbonate In N,N-dimethyl-formamide for 0.166667h; Stage #2: ethyl bromide In N,N-dimethyl-formamide for 3h; | 63% |
diethyl sulfate
(8α,9R)-10,11-dihydro-cinchonan-6',9-diol
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
With potassium hydroxide |
chloroethane
(8α,9R)-10,11-dihydro-cinchonan-6',9-diol
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
With sodium ethanolate at 75℃; im Autoklaven; |
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
durch katalytische Hydrierung; |
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
With sulphurous acid at 80℃; im Autoklaven; |
Quinine
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: palladium on carbon; hydrogen / 72 h 2.1: sodium hydride; ethanethiol / mineral oil; N,N-dimethyl-formamide / 13 h / 100 °C 3.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h 3.2: 3 h View Scheme |
dihydroquinine
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride; ethanethiol / mineral oil; N,N-dimethyl-formamide / 13 h / 100 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h 2.2: 3 h View Scheme |
(R)-4-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)hydroxymethyl-6-ethoxyquinoline
Conditions | Yield |
---|---|
durch Behandeln mit Thionylchlorid; |
IUPAC Name: (6-Ethoxy-4-quinolyl)-(5-ethylquinuclidin-2-yl)methanol
Synonyms of Hydrocupreine ethyl ether (CAS NO.522-60-1) : 6'-Ethoxy-10,11-dihydrocinchonan-9-ol ; Cinchonan-9-ol, 6'-ethoxy-10,11-dihydro- ; Cinchonan-9-ol, 6'-ethoxy-10,11-dihydro-, monohydrochloride, (8.alpha.,9R)- ; Ethylhydrocupreine ; Hydrocinchonidine, 6'-ethoxy- (7CI)
Product Categories: Miscellaneous
CAS NO: 522-60-1
Molecular Formula:C21H28N2O2
Molecular Weight :340.46
Molecular Structure :
EINECS: 208-333-5
Index of Refraction: 1.618
Surface Tension: 54.2 dyne/cm
Density: 1.18 g/cm3
Flash Point: 261.5 °C
Enthalpy of Vaporization: 82.03 kJ/mol
Boiling Point: 508.7 °C at 760 mmHg
Vapour Pressure: 3.59E-11 mmHg at 25°C
Storage Temp: Keep Hydrocupreine ethyl ether (CAS NO.522-60-1) at 2-8°C
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LDLo | oral | 400mg/kg (400mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
mouse | LDLo | subcutaneous | 24mg/kg (24mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. |
Poison by ingestion and subcutaneous routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also ETHERS.
Hazard Codes Xn
Risk Statements 22
R22: Hydrocupreine ethyl ether (CAS NO.522-60-1) is harmful if swallowed.
WGK Germany 3
RTECS MW5950000