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Name	Isoproterenol	EINECS	231-687-7
CAS No.	7683-59-2	Density	1.1240 (rough estimate)
PSA	72.72000	LogP	1.52010
Solubility	Soluble	Melting Point		165 - 170 C
Formula	C11H17 N O3	Boiling Point	350.94°C (rough estimate)
Molecular Weight	211.261	Flash Point	N/A
Transport Information	HAZARD	Appearance	white crystalline powder
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	UN NO.
Synonyms	Benzylalcohol, 3,4-dihydroxy-a-[(isopropylamino)methyl]- (8CI);1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol;3,4-Dihydroxy-a-[(isopropylamino)methyl]benzylalcohol;A 21;Aludrin;Aludrine;Asiprenol;Asmalar;Assiprenol;Bellasthman;DL(?à)-Isoproterenol;DL-Isopropylnorepinephrine;DL-Isoproterenol;Epinephrine isopropyl homolog;ICI 46399;Isonorin;Isoprenalin;Isoprenaline;Isopropydrin;Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol;Isopropylarterenol;Isopropylnoradrenaline;Isopropylnorepinephrine;Isoproterenol;Isorenin;Isupren;Lomupren;N-Isopropyl-b-dihydroxyphenyl-b-hydroxyethylamine;N-Isopropylnoradrenaline;N-Isopropylnorepinephrine;NSC 33791;NSC 9975;Neo-Epinine;Neodrenal;Norisodrine;Racemic isoprenaline;Racemic isoproterenol;Respifral;Vapo-N-Iso;dl-Isadrine;dl-Isoprenaline;dl-Isopropylnoradrenaline;dl-Isoproterenol;dl-N-Isopropylnoradrenaline;

Isoproterenol Synthetic route

2-isopropylamino-1-<3.4-dihydroxy-phenyl>-ethanone-(1)-hydrochloride: 2-isopropylamino-1-<3.4-dihydroxy-phenyl>-ethanone-(1)-hydrochloride

: 7683-59-2
isoproterenol

Conditions

Conditions	Yield
With water; palladium Hydrogenation;

2-isopropylamino-1-<3.4-dihydroxy-phenyl>-ethanone-(1)-sulfate: 2-isopropylamino-1-<3.4-dihydroxy-phenyl>-ethanone-(1)-sulfate

: 7683-59-2
isoproterenol

Conditions

Conditions	Yield
With methanol; palladium Hydrogenation;
With methanol; palladium Hydrogenation;

: 7683-59-2
isoproterenol

: 52600-52-9
5-Cyano-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

: 107-91-5
cyanoacetic acid amide

: 101184-51-4
5-cyano-2-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride	90%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride	90%

: 67-56-1
methanol

: 7683-59-2
isoproterenol

: 3868-81-3
2-(3,4-dihydroxyphenyl)-2-[(methyl)oxy]-1-(isopropylamino)ethane hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride for 0.25h; Mechanism; other derivatives of 2-alkylamino-1-(4-hydroxyphenyl)-1-ethanol;	85%
With hydrogenchloride for 0.25h;	85%
With hydrogenchloride at 10℃;	85%

: ammonium vanadate(V)

: 7683-59-2
isoproterenol

: VOOH(C6H3O2HCHOHCH2NHC3H7)2*H2O

Conditions

Conditions	Yield
With HNO3; NaOH In water (He); boiling (0.5 h, pH=6.6-6.7), gradual pptn.; washing (distd. water), drying (10E-3 mm Hg, 50°C, 3 h); elem. anal.;	76%

: 7683-59-2
isoproterenol

: 2-(chloromethyl)-2-oxo-2λ5-perhydro[1,3,2]oxazaphospholo[3,4-a]pyridine

: 2-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](isopropyl)amino]methyl-2-oxo-2λ5-perhydro[1,3,2]oxazaphospholo[3,4-a]pyridine

Conditions

Conditions	Yield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60 - 65℃; for 4h;	70%

: 7683-59-2
isoproterenol

: C13H8Cl2N3O4P

: 4-chlorophenyl-N-2-(3,4-dihydroxyphenyl)-2-hydroxyethyl-N-isopropyl-P-(5-nitro-1H-indazol-1-yl) Phosphonamidate

Conditions

Conditions	Yield
With N,N'-dimethylpiperazine In tetrahydrofuran at 50℃; for 4h;	68%

: ammonium vanadate(V)

: 7683-59-2
isoproterenol

: VO(C6H3O2COHCH2NHC3H7)2

Conditions

Conditions	Yield
With HNO3; NaOH In water boiling (0.5 h, pH=6.6-6.7), gradual pptn.; washing (distd. water), drying (10E-3 mm Hg, 50°C, 3 h); elem. anal.;	61%

: 10199-34-5, 14056-88-3, 15604-36-1
cis-dichlorobis(triphenylphosphine)platinum(II)

: 7683-59-2
isoproterenol

: 87405-03-6
Pt(P(C6H5)3)2(O2C6H3CH(OH)CH2NHCH(CH3)2)

Conditions

Conditions	Yield
With potassium hydroxide In methanol; benzene to a suspn. of substituted catechol in benzene was added MeOH soln. of KOH; prepd. soln. was syringed into suspn. of Pt complex in benzene; stirring at room temp. for 3.5 h (Ar); filtration, evapn., washing with water, drying in vac., dissoln. in CH2Cl2, filtration, evapn., washing with ether, drying in vac., crystn. from ether/hexane; elem. anal.;	50%

: 7683-59-2
isoproterenol

: 3736-31-0
N-Isopropyl-noradrenochrom

Conditions

Conditions	Yield
With water; acetic acid; potassium hexacyanoferrate(III)
With water; silver(l) oxide
With riboflavin In water UV-irradiation;

Isoproterenol Chemical Properties

Molecular Formula: C₁₁H₁₇NO₃
Molecular Weight: 211.26
EINECS: 231-687-7
Density: 1.199 g/cm³
Flash Point: 179.7 °C
Melting Point: 155.5°C
Index of Refraction: 1.579
Appearance: Off-color crystal
CAS Registry Number: 7683-59-2
Enthalpy of Vaporization: 70.73 kJ/mol
Boiling Point: 417.5 °C at 760 mmHg
Vapour Pressure: 1.02E-07 mmHg at 25°C
IUPAC Name: 4-[1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
Synonyms: 4-[1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol ; Isoproterenol ; Isoprel ; Isoprenaline ; Saventrine ; 1,2-Benzenediol, 4-1-hydroxy-2-(1-methylethyl)aminoethyl- ; 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- (9CI) ; Dl-Isadrine
Following is the molecular structure of Isoproterenol (CAS NO.7683-59-2)

Isoproterenol Uses

Isoproterenol (CAS NO.7683-59-2)'s primary use is for bradycardia or heart block. By activating β1-receptors on the heart, it induces positive chronotropic, dromotropic, and inotropic effects.
It can be used as an inhaled aerosol to treat asthma, although this is currently a rare treatment.[1] Although it activates all beta adrenergic receptors, it works in a similar fashion to the more selective β2-adrenergic agonists e.g. salbutamol, by relaxing the airways to increase airflow.
It is also supplied in ampules under the brand name Isuprel for injection and in sublingual pill form for treatment of asthma, chronic bronchitis and emphysema.
Used with caution, Isoproterenol (CAS NO.7683-59-2) can also be used to treat torsades de pointes by congenital defect, in conjunction with overdrive pacing and magnesium.
Adipose tissue also has β-receptors that can be activated by isoproterenol. Once activated, adipocytes begin breaking down the fat stored inside them. This has caused isoproterenol to be used off-label in mesotherapy for body contouring and to help decrease fat. Two studies showed that it can cause a decrease in thigh size.

Isoproterenol Toxicity Data With Reference

1.	oms-rat-par 100 mg/kg	BEXBAN Bulletin of Experimental Biology and Medicine. Translation of BEBMAE. 94 (1982),1458.
2.	dns-mus-ipr 341 mg/kg	JCLBA3 Journal of Cell Biology. 56 (1973),605.
3.	ims-hmn TDLo:14 µg/kg:CVS	KLWOAZ Klinische Wochenscrift. 19 (1940),1303.
4.	orl-rat LD50:355 mg/kg	USXXAM United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4026897 .
5.	ipr-rat LDLo:100 mg/kg	FCTXAV Food and Cosmetics Toxicology. 3 (1965),597.
6.	scu-rat LD50:600 µg/kg	TOXID9 Toxicologist. 4 (1984),77.
7.	ivn-rat LD50:57 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 16 (1970),303.
8.	orl-mus LD50:450 mg/kg	27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,139.
9.	ipr-mus LD50:440 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 164 (1968),290.
10.	scu-mus LD50:400 mg/kg	ARZNAD Arznei

Isoproterenol Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by intramuscular route: increased pulse and cardiac rate. A bronchodilator. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

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