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L(+)-Arginine

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Name

L(+)-Arginine

EINECS 200-811-1
CAS No. 74-79-3 Density 1.467 g/cm3
PSA 125.22000 LogP 0.55280
Solubility 148.7 g/L (20 °C) in water Melting Point 222 °C (dec.)(lit.)
Formula C6H14N4O2 Boiling Point 409.14 °C at 760 mmHg
Molecular Weight 174.203 Flash Point 201.241 °C
Transport Information N/A Appearance white crystalline powder
Safety 24/25-36-26 Risk Codes 36-36/37/38-20/21/22
Molecular Structure Molecular Structure of 74-79-3 (L(+)-Arginine) Hazard Symbols HarmfulXn
Synonyms

Arginine,L- (8CI);(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid;Arginine;L-Arg;L-Norvaline,5-[(aminoiminomethyl)amino]-;L-Ornithine, N5-(aminoiminomethyl)-;L-a-Amino-d-guanidinovalericacid;NSC 206269;Pentanoic acid, 2-amino-5-[(aminoiminomethyl)amino]-, (S)-;H-Arg-OH;L-Arginine (Base);L-Arginine Base;

Article Data 212

L(+)-Arginine Synthetic route

13836-37-8

Boc-Arg(Tos)-OH

74-79-3

L-arginine

Conditions
ConditionsYield
With phenylthiotrimethylsilane; pertrimethylsilylated Nafion; 3-methyl-phenol; trifluoroacetic acid for 3h;100%
68262-73-7

Z(OMe)-Arg(Mts)-OH

74-79-3

L-arginine

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 30h;100%
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed; effect of var. hard bases; var. reaction cond.;100%
2149-70-4

Nω-nitro-L-arginine

74-79-3

L-arginine

Conditions
ConditionsYield
With phenylthiotrimethylsilane; pertrimethylsilylated Nafion; 3-methyl-phenol; trifluoroacetic acid for 3h;100%
78221-85-9

cyclohexylammonium salt of Nα-benzyloxycarbonyl-NG-p-toluenesolfonyl-L-arginine

74-79-3

L-arginine

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; methoxybenzene In trifluoroacetic acid at 0℃; for 1h; Product distribution; various time, various temperature;100%
91000-69-0

Fmoc-L-Arg-OH

74-79-3

L-arginine

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 50℃; for 3h;95%
75806-97-2

NG-Mds-Arg

74-79-3

L-arginine

Conditions
ConditionsYield
With methyl-phenyl-thioether; trifluoroacetic acid at 50℃; for 4h; Product distribution; deprotection of several NG-protected arginine derivatives;94.4%
67320-28-9

Z(OMe)-Arg(MBS)-OH

74-79-3

L-arginine

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h;93.5%
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;93.5%
13650-38-9

Nα-Benzyloxycarbonyl-Nω-tosyl-L-arginin

74-79-3

L-arginine

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 1h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;86%
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h;62.1%

5-[amino(iminomethyl)]amino-2-[(E,Z)-4,4,4-trichloro-3-oxo-1-butenylamino]pentanoic acid

74-79-3

L-arginine

Conditions
ConditionsYield
With hydrogenchloride In methanol at 70℃; for 20h;83%

5-[amino(iminomethyl)]amino-2-[(E,Z)-4,4,4-trifluoro-3-oxo-1-butenylamino]pentanoic acid

74-79-3

L-arginine

Conditions
ConditionsYield
With hydrogenchloride In methanol at 70℃; for 20h;82%

L(+)-Arginine Specification

L(+)-Arginine (CAS NO.74-79-3) is also named as (S)-2-Amino-5-((aminoiminomethyl)amino)pentanoic acid. It is white crystalline powder. In mammals, L(+)-Arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. This chemical belongs to the Product Categories which include pharmacetical;chiral;Arginine [Arg, R];Amino Acids;Amino Acids and Derivatives;for Resolution of Acids;Optical Resolution;alpha-Amino Acids;Biochemistry;Synthetic Organic Chemistry;L-Amino Acids;Amino Acids;Nitric Oxide.

Physical properties about L(+)-Arginine are: (1)ACD/LogP: -0.999; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -4.50; (4)ACD/LogD (pH 7.4): -4.49; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00 ; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 6; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 6; (12)Index of Refraction: 1.601; (13)Molar Refractivity: 40.696 cm3; (14)Molar Volume: 118.724 cm3; (15)Polarizability: 16.133 10-24cm3; (16)Surface Tension: 66.1480026245117 dyne/cm; (17)Density: 1.467 g/cm3; (18)Flash Point: 201.241 °C; (19)Enthalpy of Vaporization: 72.555 kJ/mol; (20)Boiling Point: 409.14 °C at 760 mmHg

Preparation of L(+)-Arginine: L(+)-Arginine (CAS NO.74-79-3) is synthesized from citrulline by the sequential action of the cytosolic enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).

Uses of L(+)-Arginine: L(+)-Arginine plays an important role in cell division, the healing of wounds, removing ammonia from the body, immune function, and the release of hormones. It is also used as precursor for the synthesis of nitric oxide (NO). And it can reduces healing time of injuries (particularly bone), quickens repair time of damaged tissue and helps decrease blood pressure.

When you are using this chemical, please be cautious about it as the following:
1. Avoid contact with skin and eyes;
2. Wear suitable protective clothing;
3. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1).Canonical SMILES: C(CC(C(=O)O)N)CN=C(N)N
(2).Isomeric SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N
(3).InChI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
(4).InChIKey: ODKSFYDXXFIFQN-BYPYZUCNSA-N

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