• Reported in EPA TSCA Inventory.

1. Introduction of L(+)-Ornithine hydrochloride

L(+)-Ornithine hydrochloride (3184-13-2), with the IUPAC name of 2,5-diaminopentanoic acid hydrochloride, is one kind of white crystalline powder. And it belongs to the product categories which include Amino Acid Derivatives; Ornithine [Org]; Amino Acids and Derivatives; alpha-Amino Acids; Amino Acids; Biochemistry; non-Proteinorganic Amino Acids; L-Amino Acids; Amino Hydrochloride. Besides, it is , which should be stored in closed, cool and dry place.

2. Chemical properties of L(+)-Ornithine hydrochloride

The other characteristics of L(+)-Ornithine hydrochloride can be summarized as: (1)EINECS: 221-678-6; (2)ACD/LogP: -0.96; (3)# of Rule of 5 Violations: 1; (4)ACD/LogD (pH 5.5): -4.46; (5)ACD/LogD (pH 7.4): -4.36; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 4; (11)#H bond donors: 5; (12)#Freely Rotating Bonds: 6; (13)Polar Surface Area: 32.78 Å²; (14)Density: 1.57 g/cm³; (15)Flash Point: 140.5 °C; (16)Melting point: 245 °C; (17)alpha: 24 °(c=4, 6N HCl); (18)Solubility: H₂O: 100 mg/mL; (19)Enthalpy of Vaporization: 60.42 kJ/mol; (20)Boiling Point: 308.7 °C at 760 mmHg; (21)Vapour Pressure: 0.00015 mmHg at 25 °C.

3. Preparation of L-Ornithine hydrochloride 

L(+)-Ornithine hydrochloride can be prepared by the reaction of phthalimido-(3-phthalimido-propyl)-malonic acid diethyl ester with phthalic acid.



This reaction needs cc.HCl, HOAc and H₂O at temperature of 100 °C. The yield is 62 %.

4. Uses of L-Ornithine hydrochloride
 
L-Ornithine hydrochloride is used as antidote and liver function accelerating agent to treat cirrhosis. It is also used to recover disease and to invigorate health effectively. Additionally, it can be used to produce 3-amino-piperidin-2-one.



This reaction needs Al₂O₃ and toluene by heating for 3 hours. The yield is 79 %.

5. Safety information of L(+)-Ornithine hydrochloride

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-37/39-26
WGK Germany 3
RTECS RM2985000
F 3-10
HS Code 29224995

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable gloves and eye/face protection to avoid contact with skin and eyes.

6. Structure Descriptors of L(+)-Ornithine hydrochloride

People can use the following data to convert to the molecule structure.
(1)SMILES: Cl.O=C(O)C(N)CCCN
(2)InChI: InChI=1/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H
(3)InChIKey: GGTYBZJRPHEQDG-UHFFFAOYAF

7. Toxicity of L(+)-Ornithine hydrochloride

The toxicity data is as follows: