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Lincomycin A

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Name

Lincomycin A

EINECS 205-824-6
CAS No. 154-21-2 Density 1.3±0.1 g/cm3
PSA 147.79000 LogP 0.27380
Solubility N/A Melting Point 148-150 °C
Formula C18H34N2O6S Boiling Point 646.8±55.0 °C at 760 mmHg
Molecular Weight 406.544 Flash Point 345.0±31.5 °C
Transport Information N/A Appearance White crystalline solid
Safety Risk Codes  Xi:;
Molecular Structure Molecular Structure of 154-21-2 (Lincomycin) Hazard Symbols R36/37/38:;
Synonyms

D-erythro-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,trans-a- (8CI);D-erythro-a-D-galacto-Octopyranoside, methyl6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,(2S-trans)-;Lincomycin (7CI);Cillimycin;Jiemycin;Lincolcina;Lincolnensin;Lincomix;Lincomycin A;Medoglycine;U 10,149A;U 10149;Lincomycin;

Article Data 9

Lincomycin A Synthetic route

C34H61N3O9SSi3

154-21-2

lincomycin

Conditions
ConditionsYield
With potassium carbonate In methanol at 130℃; for 20h;98.4%

C26H46N5O8S(1+)

154-21-2

lincomycin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Microbiological reaction
2: Microbiological reaction
3: aq. buffer / 30 °C / Microbiological reaction
View Scheme

C34H60N4O18S

154-21-2

lincomycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Microbiological reaction
2: aq. buffer / 30 °C / Microbiological reaction
View Scheme

C22H39N3O9S

154-21-2

lincomycin

Conditions
ConditionsYield
In aq. buffer at 30℃; Microbiological reaction;

C20H37N3O8S

154-21-2

lincomycin

Conditions
ConditionsYield
With pyridoxal 5'-phosphate; LmbF enzyme; S-methyltransferase LmbG; S-adenosyl-L-methionine In aq. phosphate buffer at 30℃; for 2h; pH=7.5; Enzymatic reaction;
859-18-7

lincomycin hydrochloride

154-21-2

lincomycin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / 8 h / 2 - 20 °C
2: acetic acid / methanol / 18 h / 30 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 h / 30 °C
4: potassium carbonate / methanol / 20 h / 130 °C
View Scheme

C30H66N2O6SSi4

154-21-2

lincomycin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid / methanol / 18 h / 30 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 h / 30 °C
3: potassium carbonate / methanol / 20 h / 130 °C
View Scheme
25420-97-7

2,3,4-tris-O-(trimethylsilyl)lincomycin

154-21-2

lincomycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 h / 30 °C
2: potassium carbonate / methanol / 20 h / 130 °C
View Scheme
108-24-7

acetic anhydride

154-21-2

lincomycin

168399-17-5

(2R,3S,4S,5R,6R)-2-((1R,2R)-2-acetoxy-1-((2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
With pyridine at 20℃; for 38h; Acetylation;98.8%
75-77-4

chloro-trimethyl-silane

154-21-2

lincomycin

C30H66N2O6SSi4

Conditions
ConditionsYield
With pyridine; 1,1,1,3,3,3-hexamethyl-disilazane at 0 - 20℃; for 2h;91%

Lincomycin A Consensus Reports

EPA Genetic Toxicology Program.

Lincomycin A Specification

The Lincomycin A, with the CAS registry number 154-21-2, is also known as Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-alpha-D-gluco-octopyranoside. It belongs to the product categories of 13C & 2H Sugars; Carbohydrates & Derivatives; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 205-824-6. This chemical's molecular formula is C18H34N2O6S and molecular weight is 406.54. What's more, its systematic name is Methyl (5R)-5-[(1R,2R)-2-hydroxy-1-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}propyl]-1-thio-β-L-arabinopyranoside. Its classification codes are: (1)Anti-Bacterial Agents; (2)Anti-Infective Agents; (3)Antibacterial; (4)Drug / Therapeutic Agent; (5)Enzyme Inhibitors; (6)Mutation data; (7)Natural Product; (8)Protein Synthesis Inhibitors. This chemical is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections. 

Physical properties of Lincomycin A are: (1)ACD/LogP: 0.91±0.66; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.80; (4)ACD/LogD (pH 7.4): -0.17; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 6.26; (9)#H bond acceptors: 8; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 11; (12)Polar Surface Area: 147.79 Å2; (13)Index of Refraction: 1.583; (14)Molar Refractivity: 104.7±0.4 cm3; (15)Molar Volume: 313.3±5.0 cm3; (16)Polarizability: 41.5±0.5×10-24cm3; (17)Surface Tension: 60.7±5.0 dyne/cm; (18)Density: 1.3±0.1 g/cm3; (19)Flash Point: 345.0±31.5 °C; (20)Enthalpy of Vaporization: 109.2±6.0 kJ/mol; (21)Boiling Point: 646.8±55.0 °C at 760 mmHg; (22)Vapour Pressure: 0.0±4.4 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O
(2)Std. InChI: InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1
(3)Std. InChIKey: OJMMVQQUTAEWLP-KIDUDLJLSA-N

The toxicity data is as follows:  

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 1800mg/kg (1800mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BLOOD: OTHER CHANGES
Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(2), Pg. 40, 1990.
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Antimicrobial Agents and Chemotherapy Vol. -,
mouse LD50 intravenous 214mg/kg (214mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 913, 1965.
mouse LD50 oral 13900mg/kg (13900mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BLOOD: OTHER CHANGES
Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(2), Pg. 40, 1990.
rabbit LDLo intramuscular 200ug/kg (.2mg/kg)   Recueil de Medecine Veterinaire. Vol. 156, Pg. 915, 1980.
rat LD50 intraperitoneal 1900mg/kg (1900mg/kg) BLOOD: OTHER CHANGES

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(2), Pg. 40, 1990.
rat LD50 oral 1gm/kg (1000mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 186, 1978.
rat LD50 subcutaneous 9778mg/kg (9778mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

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