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Meclofenamic acid

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Name

Meclofenamic acid

EINECS 211-419-5
CAS No. 644-62-2 Density
Solubility Melting Point 257-259°C
Formula C14H11Cl2NO2 Boiling Point 399.4°C at 760 mmHg
Molecular Weight 296.16 Flash Point 195.3°C
Transport Information Appearance
Safety Poison by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl and NOx. Risk Codes
Molecular Structure Molecular Structure of 644-62-2 (Meclofenamic acid) Hazard Symbols
Synonyms

N-(2, 6-Dichloro-m-tolyl)anthranilic acid;benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-;Meclofenamic acid (USAN);Benzoic acid,2-[(2,6-dichloro-3-methylphenyl)- amino]-;Acido meclofenamico [INN-Spanish];Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-;2-(2, 6-Dichloro-3-methylphenyl)aminobenzoic acid;1/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19;Benzoic acid, 2-[ (2,6-dichloro-3-methylphenyl)amino]-;Meclofenamate;N-(3-Methyl-2, 6-dichlorophenyl)anthranilic acid;CL 583;Meclomen (free acid);Acide meclofenamique [INN-French];CI-583;Meclofenamic acid [USAN:BAN:INN];N-(2,6-Dichloro-3-methylphenyl)anthranilic acid;N-(2,6-Dichloro-m-tolyl)anthranilic acid;Acidum meclofenamicum [INN-Latin];Anthranilic acid, N-(2,6-dichloro-m-tolyl)-;INF 4668;2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid;2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid;2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid;Meclophenamic acid;Anthranilic acid, N- (2,6-dichloro-m-tolyl)-;N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid;Arquel;INF-4668;N-(2,6-DICHLORO-m-TOLYL)ANTHRANILIC ACID;2-((2,6-DICHLORO-3-METHYLPHENYL)AMINO)-BENZOIC ACID (9CI);

 

Meclofenamic acid Specification

Meclofenamic acid(CAS NO.644-62-2) is a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.  With the Chemical Formula of C14H11Cl2NO2, Meclofenamic acid is also called Meclofen; Meclorfenamic; Arquel; INF 4668; N-(2,6-Dichloro-m-tolyl)anthranilic Acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic Acid; NSC 95309. Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) with effects similar to those of aspirin. It is prescribed for musculoskeletal pain from soft tissue injury, bone and joint problems, and laminitis.

Physical properties about Meclofenamic acid are: (1)ACD/LogP: 5.438; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 3.55; (4)ACD/LogD (pH 7.4): 2.37; (5)ACD/BCF (pH 5.5): 103.19; (6)ACD/BCF (pH 7.4): 6.90; (7)ACD/KOC (pH 5.5): 279.32; (8)ACD/KOC (pH 7.4): 18.68; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.663; (13)Molar Refractivity: 77.172 cm3; (14)Molar Volume: 208.18 cm3; (15)Polarizability: 30.594 10-24cm3; (16)Surface Tension: 57.0439987182617 dyne/cm; (17)Density: 1.423 g/cm3; (18)Flash Point: 195.346 °C; (19)Enthalpy of Vaporization: 68.559 kJ/mol; (20)Boiling Point: 399.393 °C at 760 mmHg

You can still convert the following datas into molecular structure:
(1)InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19);
(2)InChIKey=SBDNJUWAMKYJOX-UHFFFAOYSA-N;
(3)Smilesc1c(c(ccc1)Nc1c(c(ccc1Cl)C)Cl)C(=O)O;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intraperitoneal 109mg/kg (109mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 148, Pg. 422, 1965.
rat LD50 oral 100mg/kg (100mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 7, Pg. 481, 1977.

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