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| CAS No.: | 644-62-2 |
|---|---|
| Name: | Meclofenamic acid |
| Molecular Structure: | |
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| Formula: | C14H11Cl2NO2 |
| Molecular Weight: | 296.153 |
| Synonyms: | N-(2, 6-Dichloro-m-tolyl)anthranilic acid;benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-;Meclofenamic acid (USAN);Benzoic acid,2-[(2,6-dichloro-3-methylphenyl)- amino]-;Acido meclofenamico [INN-Spanish];Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-;2-(2, 6-Dichloro-3-methylphenyl)aminobenzoic acid;1/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19;Benzoic acid, 2-[ (2,6-dichloro-3-methylphenyl)amino]-;Meclofenamate;N-(3-Methyl-2, 6-dichlorophenyl)anthranilic acid;CL 583;Meclomen (free acid);Acide meclofenamique [INN-French];CI-583;Meclofenamic acid [USAN:BAN:INN];N-(2,6-Dichloro-3-methylphenyl)anthranilic acid;N-(2,6-Dichloro-m-tolyl)anthranilic acid;Acidum meclofenamicum [INN-Latin];Anthranilic acid, N-(2,6-dichloro-m-tolyl)-;INF 4668;2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid;2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid;2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid;Meclophenamic acid;Anthranilic acid, N- (2,6-dichloro-m-tolyl)-;N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid;Arquel;INF-4668;N-(2,6-DICHLORO-m-TOLYL)ANTHRANILIC ACID;2-((2,6-DICHLORO-3-METHYLPHENYL)AMINO)-BENZOIC ACID (9CI); |
| EINECS: | 211-419-5 |
| Density: | 1.3567 (rough estimate) |
| Melting Point: | 257-259°C |
| Boiling Point: | 399.4°C at 760 mmHg |
| Flash Point: | 195.3°C |
| Safety: | Poison by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. |
| PSA: | 49.33000 |
| LogP: | 4.81660 |
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2,6-dichloro-3-methylaniline
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Diphenyliodonium-2-carboxylate
- 644-62-2
MECLOFENAMIC ACID
| Conditions | Yield |
|---|---|
| With copper diacetate | 70% |
| With copper diacetate In isopropyl alcohol for 20h; Heating; | 0.9 g |
| Conditions | Yield |
|---|---|
| With potassium carbonate; copper In N,N-dimethyl-formamide for 2h; Heating; | 18% |
| Conditions | Yield |
|---|---|
| With N-ethylmorpholine;; copper diacetate In N,N-dimethyl-formamide at 145℃; for 3h; |
- 13625-29-1
1,3-bis-(2,6-dichloro-3-methyl-phenyl)-1H-quinazoline-2,4-dione
- 644-62-2
MECLOFENAMIC ACID
| Conditions | Yield |
|---|---|
| With potassium hydroxide In ethylene glycol |
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In methanol | |
| With hydrazine hydrate In methanol |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In monoethylene glycol diethyl ether |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water |
- 644-62-2
MECLOFENAMIC ACID
| Conditions | Yield |
|---|---|
| With water; sodium hydroxide In tetrahydrofuran; ethanol |
| Conditions | Yield |
|---|---|
| In methanol at 20℃; | 100% |
- 79-37-8
oxalyl dichloride
- 644-62-2
MECLOFENAMIC ACID
- 3254-79-3
2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid,methyl ester
| Conditions | Yield |
|---|---|
| In N-methyl-acetamide; methanol; dichloromethane | 94% |
| 89% |
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Specification
Meclofenamic acid(CAS NO.644-62-2) is a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. With the Chemical Formula of C14H11Cl2NO2, Meclofenamic acid is also called Meclofen; Meclorfenamic; Arquel; INF 4668; N-(2,6-Dichloro-m-tolyl)anthranilic Acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic Acid; NSC 95309. Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) with effects similar to those of aspirin. It is prescribed for musculoskeletal pain from soft tissue injury, bone and joint problems, and laminitis.
Physical properties about Meclofenamic acid are: (1)ACD/LogP: 5.438; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 3.55; (4)ACD/LogD (pH 7.4): 2.37; (5)ACD/BCF (pH 5.5): 103.19; (6)ACD/BCF (pH 7.4): 6.90; (7)ACD/KOC (pH 5.5): 279.32; (8)ACD/KOC (pH 7.4): 18.68; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.663; (13)Molar Refractivity: 77.172 cm3; (14)Molar Volume: 208.18 cm3; (15)Polarizability: 30.594 10-24cm3; (16)Surface Tension: 57.0439987182617 dyne/cm; (17)Density: 1.423 g/cm3; (18)Flash Point: 195.346 °C; (19)Enthalpy of Vaporization: 68.559 kJ/mol; (20)Boiling Point: 399.393 °C at 760 mmHg
You can still convert the following datas into molecular structure:
(1)InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19);
(2)InChIKey=SBDNJUWAMKYJOX-UHFFFAOYSA-N;
(3)Smilesc1c(c(ccc1)Nc1c(c(ccc1Cl)C)Cl)C(=O)O;
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intraperitoneal | 109mg/kg (109mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 148, Pg. 422, 1965. | |
| rat | LD50 | oral | 100mg/kg (100mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 7, Pg. 481, 1977. |