- Methdilazine
- Methdilazine hydrochloride
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Cas Database |
| Name |
Methdilazine |
EINECS | 217-841-6 |
| CAS No. | 1982-37-2 | Density | 1.185 g/cm3 |
| PSA | 31.78000 | LogP | 4.24390 |
| Solubility | N/A | Melting Point |
87-88℃ |
| Formula | C18H20 N2 S | Boiling Point | 430.4 ºC at 760 mmHg |
| Molecular Weight | 296.436 | Flash Point | 214.1 ºC |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, dyspnea and gastrointestinal changes. When heated to decomposition it emits very toxic fumes of SOx and NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]- (6CI,7CI,8CI);10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine;10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine; MJ 5022; Methdilazine |
Article Data | 7 |
Methdilazine Synthetic route
| Conditions | Yield |
|---|---|
| With sodium amide |
Methdilazine Chemical Properties
IUPAC Name: 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine
The MF of 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2) is C18H20N2S.
The MW of 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2) is 296.4298.
Synonyms of 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2): Methdilazine (200 mg) ; 10-((1-Methyl-3-pyrrolidinyl)methyl)-phenothiazin ; 10-((1-Methyl-3-pyrrolidinyl)methyl)-phenothiazine ; 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10h-phenothiazine ; 10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine ; 10H-Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]- ; Dilosyn ; Disyncram
Index of Refraction: 1.642
Form: Crystals
EINECS: 217-841-6
Density: 1.185 g/ml
Flash Point: 214.1 °C
Boiling Point: 430.4 °C
Sensitive: sensitive to light
Methdilazine Uses
10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2) is used as antihistamines.
Methdilazine Toxicity Data With Reference
| 1. | orl-hmn TDLo:4 mg/kg:CNS,GIT,PUL | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,379. | ||
| 2. | orl-rat LD50:162 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185. | ||
| 3. | orl-mus LD50:225 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,29. | ||
| 4. | ipr-mus LD50:183 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,29. | ||
| 5. | orl-gpg LD50:263 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,29. |
Methdilazine Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, dyspnea and gastrointestinal changes. When heated to decomposition it emits very toxic fumes of SOx and NOx.
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