Basic Information | Post buying leads | Suppliers |
The Methoxamine hydrochloride with CAS registry number of 61-16-5 is also called Benzenemethanol,a-(1-aminoethyl)-2,5-dimethoxy-,hydrochloride(1:1). The IUPAC name is 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol hydrochloride. Its EINECS registry number is 200-499-7. In addition, the molecular formula is C11H17NO3.ClH and the molecular weight is 247.72. It is an alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction.
Physical properties about Methoxamine hydrochloride are: (1)ACD/LogP: 0.69 ; (2)ACD/LogD (pH 5.5): -2.3; (3)ACD/LogD (pH 7.4): -1.02; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1.1; (8)#H bond acceptors: 4; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 6; (11)Polar Surface Area: 30.93 Å2; (12)Flash Point: 176.6 °C; (13)Enthalpy of Vaporization: 64.88 kJ/mol; (14)Boiling Point: 368.4 °C at 760 mmHg; (15)Vapour Pressure: 4.47E-06 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: Cl.O(c1ccc(OC)cc1C(O)C(N)C)C
(2)InChI: InChI=1/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H
(3)InChIKey: YGRFXPCHZBRUKP-UHFFFAOYAI
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 92mg/kg (92mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 283, 1948. |
mouse | LD50 | intravenous | 5030ug/kg (5.03mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA | European Journal of Pharmacology. Vol. 9, Pg. 289, 1970. |
mouse | LDLo | oral | 135mg/kg (135mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 160, 1973. |