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Cas Database |
| Name |
Metoprolol |
EINECS | 253-483-7 |
| CAS No. | 37350-58-6 | Density | 1.033 g/cm3 |
| PSA | 50.72000 | LogP | 2.00410 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C15H25NO3 | Boiling Point | 398.6 °C at 760 mmHg |
| Molecular Weight | 267.37 | Flash Point | 194.9 °C |
| Transport Information | N/A | Appearance | powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-;1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol;Corvitol;Minax;Presolol;Seroken;Toprol;UNII-GEB06NHM23; |
Article Data | 47 |
Metoprolol Chemical Properties
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IUPAC Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
Molecular Formula: C15H25NO3
Molecular Weight: 267.36 g/mol
Product Categories: Cardiovascular
EINECS: 253-483-7
Classification Code: Adrenergic Agents; Adrenergic Antagonists; Adrenergic beta-antagonists; Anti-adrenergic [beta-receptor]; Anti-arrhythmia agents; Antihypertensive agents; Autonomic Agents; Cardiovascular Agents; Drug / Therapeutic Agent; Human Data; Neurotransmitter Agents; Peripheral Nervous System Agents; Reproductive Effect; Sympatholytics
Index of Refraction: 1.507
Molar Refractivity: 77.07 cm3
Molar Volume: 258.7 cm3
Surface Tension: 37 dyne/cm
Density: 1.033 g/cm3
Flash Point: 194.9 °C
Enthalpy of Vaporization: 68.47 kJ/mol
Boiling Point: 398.6 °C at 760 mmHg
Vapour Pressure of Metoprolol (CAS NO.37350-58-6): 4.52E-07 mmHg at 25 °C
Metoprolol Uses
Metoprolol (CAS NO.37350-58-6) is used as a treatment for high blood pressure drugs, mainly the use of its tartaric acid salt. It also used its hydrochloride. Metoprolol right selective β1 adrenergic receptor blocking effect on the role of β2 receptor is weak, a larger dose of blood vessels and bronchial smooth muscle contraction can, and have a weak role of membrane stabilizing agent, without intrinsic sympathomimetic activity. Can slow down the heart rate, reduce cardiac output and myocardial oxygen consumption, as well as lower blood pressure. Primarily used to treat angina and hypertension. Used to treat high blood pressure and angina pectoris.
Metoprolol Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 60mg/kg (60mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 186, 1979. | |
| mouse | LD50 | intraperitoneal | > 200mg/kg (200mg/kg) | Farmaco, Edizione Scientifica. Vol. 41, Pg. 80, 1986. | |
| mouse | LD50 | intravenous | 62mg/kg (62mg/kg) | United States Patent Document. Vol. #4252984, | |
| mouse | LD50 | oral | 1050mg/kg (1050mg/kg) | United States Patent Document. Vol. #4252984, | |
| mouse | LD50 | subcutaneous | > 600mg/kg (600mg/kg) | Collection of Czechoslovak Chemical Communications. Vol. 50, Pg. 2289, 1985. | |
| rat | LD50 | intravenous | 71900ug/kg (71.9mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977. | |
| rat | LD50 | oral | 3470mg/kg (3470mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977. | |
| women | TDLo | oral | 17mg/kg/17D-I (17mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: EXCITEMENT | Annals of Internal Medicine. Vol. 108, Pg. 67, 1988. |
| women | TDLo | oral | 150mg/kg (150mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: SLEEP CARDIAC: CHANGE IN FORCE OF CONTRACTION | Acta Medica Scandinavica. Vol. 218, Pg. 525, 1985. |
Metoprolol Safety Profile
Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: cardiac, eye, and behavioral effects. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Metoprolol Specification
Metoprolol (CAS NO.37350-58-6), its Synonyms are (RS)-Metoprolol ; 1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol ; 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)- ; Beatrolol ; Preblok ; Presolol ; Spesicor ; dl-Metoprolol .
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