The N-Carbethoxyphthalimide, with the CAS registry number 22509-74-6, is also known as Ethyl 1,3-dioxo-1,3-dihydro-2H-isoindole-2-carboxylate. It belongs to the product categories of Biochemistry; N-Substituted Maleimides, Succinimides & Phthalimides; N-Substituted Phthalimides; Peptide Synthesis; Protection & Derivatization Reagents (for Synthesis); Protective Reagents (Peptide Synthesis); Synthetic Organic Chemistry. Its EINECS registry number is 245-048-5. This chemical's molecular formula is C₁₁H₉NO₄ and molecular weight is 219.19. What's more, its IUPAC name is called Ethyl 1,3-dioxoisoindole-2-carboxylate.

Physical properties about N-Carbethoxyphthalimide are: (1)ACD/LogP: 1.472; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.47; (4)ACD/LogD (pH 7.4): 1.47; (5)ACD/BCF (pH 5.5): 7.74; (6)ACD/BCF (pH 7.4): 7.74; (7)ACD/KOC (pH 5.5): 150.62; (8)ACD/KOC (pH 7.4): 150.62; (9)#H bond acceptors: 5 ; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 63.68 Å²; (13)Index of Refraction: 1.595; (14)Molar Refractivity: 53.226 cm³; (15)Molar Volume: 156.701 cm³; (16)Polarizability: 21.101×10^-24cm³; (17)Surface Tension: 59.296 dyne/cm; (18)Density: 1.399 g/cm³; (19)Flash Point: 167.815 °C; (20)Enthalpy of Vaporization: 59.884 kJ/mol; (21)Boiling Point: 353.871 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.

Preparation of N-Carbethoxyphthalimide: this chemical can be prepared by carbonochloridic acid ethyl ester with phthalimide; potassium salt. This reaction needs reagent 18-crown-6 and solvent toluene at temperature of 90 °C. The reaction time is 1 hour. The yield is 96 %.

Uses of N-Carbethoxyphthalimide: it is used to produce other chemicals. For example, it can react with 2-pyridin-3-yl-ethylamine to get 3-(2-phthalimidoethyl)pyridine. This reaction needs solvent ethanol at temperature of 60 °C. The reaction time is 0.5 hour. The yield is 58 %.

When you are dealing with this chemical, you should be very careful. This chemical may cause inflammation to the skin, eyes and respiratory system or other mucous membranes. Therefore, you should avoid contacting with skin, eyes and wear suitable protective clothing, gloves. The gas can not be breathed. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C2c1ccccc1C(=O)N2C(=O)OCC
(2) InChI: InChI=1S/C11H9NO4/c1-2-16-11(15)12-9(13)7-5-3-4-6-8(7)10(12)14/h3-6H,2H2,1H3
(3) InChIKey: VRHAQNTWKSVEEC-UHFFFAOYSA-N