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N-Ethyl-D-glucamine

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Name

N-Ethyl-D-glucamine

EINECS 238-073-8
CAS No. 14216-22-9 Density 1.32 g/cm3
PSA 113.18000 LogP -2.57730
Solubility 0.1 g/mL in water clear, colorless Melting Point 136-140 °C
Formula C8H19NO5 Boiling Point 489.8 °C at 760 mmHg
Molecular Weight 209.243 Flash Point 235.6 °C
Transport Information N/A Appearance White crystalline powder, odourless or almost odourless
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 14216-22-9 (N-Ethyl-D-glucamine) Hazard Symbols IrritantXi
Synonyms

Glucitol,1-deoxy-1-(ethylamino)- (7CI);Glucitol, 1-deoxy-1-(ethylamino)-, D- (8CI);Sorbitol, 1-deoxy-1-ethylamino- (6CI);D-(-)-N-Ethylglucamine;Eglumine;N-Ethylglucamine;

 

N-Ethyl-D-glucamine Synthetic route

50-99-7

D-glucose

75-04-7

ethylamine

14216-22-9

N-ethyl-D-glucamine

Conditions
ConditionsYield
Stage #1: D-glucose; ethylamine With hydrogen In methanol at 25 - 35℃; for 0.5h;
Stage #2: In methanol at 60 - 80℃; for 12h; Reagent/catalyst; Solvent; Sealed tube; Inert atmosphere;
95.69%
With nickel kieselguhr; water at 90 - 100℃; under 73550.8 Torr; Hydrogenation;
With nickel kieselguhr; water at 90 - 100℃; under 73550.8 Torr; Hydrogenation;
N-ethyl-D-glucosylamine

N-ethyl-D-glucosylamine

14216-22-9

N-ethyl-D-glucamine

Conditions
ConditionsYield
With methanol; palladium on activated charcoal at 15 - 40℃; under 18387.7 Torr; Hydrogenation;
67-56-1

methanol

D-glucose-ethylimine

palladium

palladium

coal

coal

14216-22-9

N-ethyl-D-glucamine

Conditions
ConditionsYield
at 15 - 40℃; under 18387.7 Torr; Hydrogenation;
14216-22-9

N-ethyl-D-glucamine

620-23-5

m-tolyl aldehyde

(2R,5S)-3-ethyl-2-(3-methylphenyl)-5-(D-arabino-1,2,3,4-tetrahydroxybutyl)oxazolidine

Conditions
ConditionsYield
In benzene Dean-Stark; Reflux;74%
14216-22-9

N-ethyl-D-glucamine

591-31-1

3-methoxy-benzaldehyde

(2R,5S)-3-ethyl-2-(3-methoxyphenyl)-5-(D-arabino-1,2,3,4-tetrahydroxybutyl)oxazolidine

Conditions
ConditionsYield
In benzene Dean-Stark; Reflux;74%
14216-22-9

N-ethyl-D-glucamine

104-87-0

4-methyl-benzaldehyde

(2R,5S)-3-ethyl-2-(4-methylphenyl)-5-(D-arabino-1,2,3,4-tetrahydroxybutyl)oxazolidine

Conditions
ConditionsYield
In benzene Dean-Stark; Reflux;71%
14216-22-9

N-ethyl-D-glucamine

C23H20ClNO4S

C31H38N2O9S

Conditions
ConditionsYield
In water; isopropyl alcohol at 80℃; for 13h;59%
14216-22-9

N-ethyl-D-glucamine

555-16-8

4-nitrobenzaldehdye

(5S)-3-ethyl-2-(4-nitrophenyl)-5-(D-arabino-1,2,3,4-tetrahydroxybutyl)oxazolidine

Conditions
ConditionsYield
In methanol; water Heating; Green chemistry;52%
14216-22-9

N-ethyl-D-glucamine

122-03-2

(4-isopropylbenzaldehyde)

(2R,5S)-3-ethyl-2-(4-isopropylphenyl)-5-(D-arabino-1,2,3,4-tetrahydroxybutyl)oxazolidine

Conditions
ConditionsYield
In benzene Dean-Stark; Reflux;49%
14216-22-9

N-ethyl-D-glucamine

chromium(III) trifluoride tetrahydrate

Ni(2+)*CO3(2-)*(x)H2O*2HO(1-)*Ni(2+)

75-98-9

Trimethylacetic acid

[Cr7NiF3(N-ethyl-D-glucamine)(O2CtBu)15(H2O)]

Conditions
ConditionsYield
Stage #1: N-ethyl-D-glucamine; chromium(III) trifluoride tetrahydrate; Trimethylacetic acid at 160℃; for 2h;
Stage #2: Ni(2+)*CO3(2-)*(x)H2O*2HO(1-)*Ni(2+) at 160℃; for 50h;
43%

N-Ethyl-D-glucamine Specification

The N-Ethylglucamine, with the CAS registry number 59486-73-6, is also known as 1-Deoxy-1-(ethylamino)-D-glucitol. It belongs to the product categories of Inorganic & Organic Chemicals; Carbohydrate Synthesis; Monosaccharides; Specialty Synthesis. Its EINECS registry number is 238-073-8. This chemical's molecular formula is C8H19NO5 and molecular weight is 209.24. Its systematic name is called 1-deoxy-1-(ethylamino)-D-glucitol.

Physical properties of N-Ethylglucamine: (1)ACD/LogP: -2.84; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -5.83; (4)ACD/LogD (pH 7.4): -4.57; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 6; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 12; (12)Index of Refraction: 1.546; (13)Molar Refractivity: 50.21 cm3; (14)Molar Volume: 158.4 cm3; (15)Surface Tension: 65.9 dyne/cm; (16)Density: 1.32 g/cm3; (17)Flash Point: 235.6 °C; (18)Enthalpy of Vaporization: 87.11 kJ/mol; (19)Boiling Point: 489.8 °C at 760 mmHg; (20)Vapour Pressure: 1.2E-11 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: O[C@H]([C@@H](O)CNCC)[C@H](O)[C@H](O)CO
(2)InChI: InChI=1/C8H19NO5/c1-2-9-3-5(11)7(13)8(14)6(12)4-10/h5-14H,2-4H2,1H3/t5-,6+,7+,8+/m0/s1
(3)InChIKey: IKXCHOUDIPZROZ-LXGUWJNJBS

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