- PHYSOSTIGMINE
- Physostigmine methiodide
- PHYSOSTIGMINE SALICYLATE (1:1)
- Physostigmine sulfate
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| Name |
Physostigmine sulfate |
EINECS | N/A |
| CAS No. | 64-47-1 | Density | 1.0911 (rough estimate) |
| PSA | 172.60000 | LogP | 4.76340 |
| Solubility | N/A | Melting Point |
140° (after drying at 100°) |
| Formula | C30H42N6O4S | Boiling Point | 557.5°C at 760 mmHg |
| Molecular Weight | 646.84 | Flash Point | 291°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by subcutaneous route: hallucinations or distorted perceptions; nausea or vomiting, and other gastrointestinal changes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx. See also PHYSOSTIGMINE. | Risk Codes | R26/28 |
| Molecular Structure |
|
Hazard Symbols |
 T+
|
| Synonyms |
(3as-cis)-amate(estersulfate(2:1)(salt);(3as-cis)-ylcarbamate(estersulfate(2:1);3-b)indole,1,2,3,3a,8,8a-hexahydro-5-hydroxy-1,3a,8-trimethyl-pyrrolo(meth;eserinesulphate;physostigmineso4;physostigminesulphate;ESERINE SULFATE;ESERINE HEMISULFATE |
Physostigmine sulfate Chemical Properties
Empirical Formula: C30H44N6O8S
Molecular Weight: 648.7708 g/mol
EINECS: 200-585-4
Flash Point: 191.8 °C
Boiling Point: 393.5 °C at 760 mmHg
Vapour Pressure: 2.12E-06 mmHg at 25 °C
Storage tempreture: 2-8 °C
Structure of Physostigmine sulfate (CAS NO.64-47-1):
.png)
IUPAC Name: [(3aR,8bS)-3,4,8b-Trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl]N-methylcarbamate; sulfuric acid
Product Categories of Physostigmine sulfate (CAS NO.64-47-1): Acetylcholine receptor
Physostigmine sulfate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | subcutaneous | 1250ug/kg (1.25mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932. |
| frog | LDLo | parenteral | 325mg/kg (325mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932. | |
| frog | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 207, Pg. 547, 1949. | |
| man | TDLo | subcutaneous | 191ng/kg (0.000191mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 53, Pg. 313, 1905. |
| mouse | LD50 | intraperitoneal | 510ug/kg (0.51mg/kg) | Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972. | |
| mouse | LD50 | intravenous | 178ug/kg (0.178mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03167, | |
| mouse | LD50 | oral | 1680ug/kg (1.68mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 137, 1972. | |
| mouse | LD50 | subcutaneous | 700ug/kg (0.7mg/kg) | Annales Pharmaceutiques Francaises. Vol. 11, Pg. 286, 1953. | |
| rabbit | LDLo | subcutaneous | 1500ug/kg (1.5mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932. |
| rat | LD50 | intraperitoneal | 1621ug/kg (1.621mg/kg) | Fundamental and Applied Toxicology. Vol. 4, Pg. S195, 1984. | |
| rat | LD50 | intravenous | 450ug/kg (0.45mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 259, Pg. 153, 1982. | |
| rat | LD50 | oral | 4mg/kg (4mg/kg) | Annales Pharmaceutiques Francaises. Vol. 11, Pg. 286, 1953. |
Physostigmine sulfate Consensus Reports
EPA Genetic Toxicology Program.
Physostigmine sulfate Safety Profile
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by subcutaneous route: hallucinations or distorted perceptions; nausea or vomiting, and other gastrointestinal changes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx. See also PHYSOSTIGMINE.
Hazard Codes of Physostigmine sulfate (CAS NO.64-47-1): 
T+
Risk Statements: 26/28
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements: 25-45
S25:Avoid contact with eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Physostigmine sulfate Specification
Physostigmine sulfate ,its cas register number is 64-47-1. It also can be called Sulfuric acid compd. with physostigmine (1:2) ; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol Methylcarbamate (Ester) Sulfate (2:1) ; and Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, sulfate (2:1) (salt) .
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