Pregabalin was first developed by medicinal chemist Richard Bruce Silverman at Northwestern University in the United States. In 2004,The drug was approved in the European Union. Pregabalin received U.S. FDA approval for use in treating epilepsy, diabetic neuropathy pain and post-herpetic neuralgia in December 2004, and appeared on the U.S. market in fall 2005.

1. Introduction of Pregabalin
Pregabalin is one kind of white or almost white crystalline powder or off-white solid. The IUPAC name of this chemical is (3S)-3-(aminomethyl)-5-methylhexanoic acid. The product's categories are APIs; Miscellaneous Biochemicals; Intermediates & Fine Chemicals; Neurochemicals; Pharmaceuticals; API. Besides, the Classification Code of it is Analgesics; Anticonvulsant; Anticonvulsants; Central Nervous System Agents; Peripheral Nervous System Agents; Sensory System Agents. It is freely soluble in water and both basic and acidic aqueous solutions. The Pregabalin is an organic compound.

2. Properties of Pregabalin
Physical properties about Pregabalin are:
(1)ACD/LogP: 1.12; (2)ACD/LogD (pH 5.5): -1.39; (3)ACD/LogD (pH 7.4): -1.38; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 6; (11)Polar Surface Area: 29.54 Å²; (12)Index of Refraction: 1.464; (13)Molar Refractivity: 44.12 cm³; (14)Molar Volume: 159.6 cm³; (15)Polarizability: 17.49×10^-24cm³; (16)Surface Tension: 37.8 dyne/cm; (17)Density: 0.997 g/cm³; (18)Flash Point: 119.5 °C; (19)Enthalpy of Vaporization: 56.4 kJ/mol; (20)Boiling Point: 274 °C at 760 mmHg; (21)Vapour Pressure: 0.00153 mmHg at 25°C.

3. Structure Descriptors of Pregabalin
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)C[C@H](CC(C)C)CN
(2)InChI: InChI=1/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
(3)InChIKey: AYXYPKUFHZROOJ-ZETCQYMHBI
(4)Std. InChI: InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
(5)Std. InChIKey: AYXYPKUFHZROOJ-ZETCQYMHSA-N

4. Uses of Pregabalin
Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. It has also been found effective for generalized anxiety disorder and is approved for this use in the European Union. It was designed as a more potent successor to gabapentin. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. It can be used as anticonvulsion, anti-epileptic drug.