Retinol palmitate

Base Information Edit

Chemical Name:Retinol palmitate
CAS No.:79-81-2
Deprecated CAS:108066-99-5,37340-08-2,7488-89-3,674786-07-3,37340-08-2,674786-07-3
Molecular Formula:C36H60O2
Molecular Weight:524.871
Hs Code.:29362100
European Community (EC) Number:201-228-5
UNII:1D1K0N0VVC
ChEMBL ID:CHEMBL1675
DSSTox Substance ID:DTXSID1021241
Metabolomics Workbench ID:29036
NCI Thesaurus Code:C1217
Nikkaji Number:J3.849K
NSC Number:758478
Pharos Ligand ID:WTRWPT3R4WHL
RXCUI:35406
Wikidata:Q7316807
Wikipedia:Retinyl_palmitate
Mol file:79-81-2.mol

Synonyms:Retinolpalmitate (6CI,7CI);Retinol, palmitate, all-trans- (8CI);250S/N;250S/N-B;Aquapalm;Aquasol A;Arovit;Arovit (Roche);Axerophthol palmitate;DispatabsTabs;Lutavit A 500 Plus;Optovit A;Palmitic acid, ester withretinol;Retinyl palmitate;Testavol S;VAP 250CK-CWD;VAP 250MS-CWD;Vitamin Apalmitate;Vitazyme A;all-trans-Retinol palmitate;all-trans-Vitamin A palmitate;trans-Retinyl palmitate;Vitamin A palmitate;

Suppliers and Price of Retinol palmitate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
all-trans-RetinylPalmitate
5g
$ 70.00

TRC
all-trans-RetinylPalmitate
25g
$ 155.00

Sigma-Aldrich
Retinyl palmitate Type IV, ~1,800,000 USP units/g, oil
100g
$ 1090.00

Sigma-Aldrich
Retinyl palmitate United States Pharmacopeia (USP) Reference Standard
4x50mg
$ 371.00

Sigma-Aldrich
Retinyl palmitate Type IV, ~1,800,000 USP units/g, oil
5g
$ 250.00

Sigma-Aldrich
Retinyl palmitate potency: ≥1,700,000?USP units per g
25g
$ 178.00

Sigma-Aldrich
Retinyl palmitate solution 100 μg/mL (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, certified reference material
012-1ml
$ 89.40

Sigma-Aldrich
Retinyl Palmitate (Vitamin A Palmitate) Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 72.80

Sigma-Aldrich
Retinol palmitate analytical standard
100 mg
$ 27.80

Sigma-Aldrich
Retinol palmitate analytical standard
u
$ 26.90

Total 222 raw suppliers

Chemical Property of Retinol palmitate Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:2-8 °C
Refractive Index:1.511
Boiling Point:607.5 °C at 760 mmHg
Flash Point:79.7 °C
PSA：26.30000
Density:0.92 g/cm³
LogP:11.54250
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
Water Solubility.:Soluble in chloroform, ether, and vegetable oils. Insoluble in water.
XLogP3:13.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:21
Exact Mass:524.45933115
Heavy Atom Count:38
Complexity:803

Purity/Quality:

99%min ^*data from raw suppliers

all-trans-RetinylPalmitate ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,Xn
Hazard Codes:T,Xn,F
Statements: 63-53-61-11
Safety Statements: 53-23-36/37/39-45-36/37-16-60

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C
Isomeric SMILES:CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(CCCC1(C)C)C
Recent ClinicalTrials:Vitamin A Palmitate Supplementation in People With Age-Related Macular Degeneration (and Without Reticular Pseudodrusen) and Delayed Dark Adaptation
Recent EU Clinical Trials:A prospective, multicenter, double blind, placebo-controlled, two-arm parallel group phase 3 trial to evaluate the effect of early postnatal additional high dose oral vitamin A supplementation of 5000 IU/kg/d versus placebo for 28 days for preventing bronchopulmonary dysplasia (BPD) or death in extremely-low-birth-weight (ELBW) infants.
Recent NIPH Clinical Trials:Efficacy and safety assessment of retinol palmitate (Vitamin A) for acute brain infarction, phaseI and multi-center, randomized controlled, phaseII trial.
Uses antihypertensive all-trans-Retinyl Palmitate is an ester derivative of Retinol (R252000). all-trans-Retinyl Palmitate is used as a vitamin supplement in the treatment of Vitamin A deficiency. all-trans-Retinyl Palmita te is used as an antioxidant and a source of vitamin A added to low fat milk and other dairy products. all-trans-Retinyl Palmitate is also a constituent of some topically applied skin care products retinyl palmitate is a skin conditioner. This retinoid is considered a milder version of retinoic acid, given its conversion properties. once on the skin, it converts to retinol, which in turn converts to retinoic acid. Physiologically, it is credited with increasing R epidermal thickness, stimulating the production of more epidermal protein, and increasing skin elasticity. Cosmetically, retinyl palmitate is used to reduce the number and depth of fine lines and wrinkles, and prevent skin roughness resulting from uV exposure. Secondary reactions such as erythema, dryness, or irritation are not associated with retinyl palmitate. It is even more effective when used in combination with glycolic acid because it achieves greater penetration. In the united States, its maximum usage level in cosmetic formulations is 2 percent. Retinyl palmitate is the ester of retinol and palmitic acid. vitamin A palmitate is known as a skin “normalizer.” It acts as an antikeratinizing agent, helping the skin stay soft and plump, and improving its water-barrier properties. Because of its impact on the skin’s water-barrier properties, it is useful against dryness, heat, and pollution. It is also an anti-oxidant and is suggested for use in sunscreens. Clinical studies with vitamin A palmitate indicate a significant change in skin composition, with increases in collagen, DnA, skin thickness, and elasticity. Vitamin A palmitate’s stability is superior to retinol.

Technology Process of Retinol palmitate

There total 30 articles about Retinol palmitate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 68-26-8
RETINOL

: 112-67-4
n-hexadecanoyl chloride

: 79-81-2
retinyl palmitate

Guidance literature:: In toluene; at 35 ℃; for 1h;

Reference yield: 97.62%

: 623-65-4
palmitic anhydride

: 68-26-8
RETINOL

: 79-81-2
retinyl palmitate

Guidance literature:: With aluminum oxide; In Petroleum ether; at 40 ℃; for 2h; Solvent;

Reference yield: 96.0%

: 112-39-0
hexadecanoic acid methyl ester

: 127-47-9,64536-04-5
Retinol acetate

: 79-81-2
retinyl palmitate

Guidance literature:: With sodium hydroxide; In methanol; at 55 ℃; for 3h; under 11.2511 - 16.5017 Torr; Concentration; Pressure; Large scale;