Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]
CAS No.:291299-79-1
Molecular Formula:C₅₀H₆₃N₄O₁₀P
Molecular Weight:911.045
Hs Code.:
Mol file:291299-79-1.mol

Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-,
3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl
bis(1-methylethyl)phosphoramidite]

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]

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Technology Process of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]

There total 7 articles about Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 327596-87-2
N,N,N',N'-tetraisopropyl-O-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethyl] phosphordiamidite

: 291299-79-1,291299-99-5,291300-01-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyl-2'-deoxythymidine

Guidance literature:: With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/ja0016396

Reference yield:

: 104655-84-7
5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite

: 291299-78-0
N-(2-hydroxyethyl)-N-isopropyl-4-methoxybenzamide

: 291299-79-1,291299-99-5,291300-01-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyl-2'-deoxythymidine

Guidance literature:: With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/ja0016396

Reference yield:

: 109-56-8
i-propyl(2-(hydroxy)ethyl)amine

: 291299-79-1,291299-99-5,291300-01-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / tetrahydrofuran / 2 h / 20 °C

2: 84.5 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0.17 h / -78 °C

3: 97.6 percent / 1H-tetrazole / acetonitrile; CH₂Cl₂ / 2 h / 20 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ja0016396