N,N-DIETHYLGLYCINE METHYL ESTER

Base Information

• Chemical Name: N,N-DIETHYLGLYCINE METHYL ESTER
• CAS No.: 30280-35-4
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Hs Code.: 2922499990
• Mol file: 30280-35-4.mol

Synonyms:N,N-Diaethyl-glycin-methylester;methyl N,N-diethylglycine;N,N-Diethylglycine Methyl Ester;methyl n,n-diethylglycinate;methyl diethylaminoacetate;N,N-diethyl-glycine methyl ester;

Chemical Property of N,N-DIETHYLGLYCINE METHYL ESTER

Chemical Property:

• Refractive Index: 1.4220-1.4250
• Boiling Point: 86oC / 57mmHg
• PKA: 8.33±0.25(Predicted)
• Flash Point: 54.6oC
• PSA: 29.54000
• Density: 0.93
• LogP: 0.50120
• Storage Temp.: 0-10°C

Purity/Quality:

98% ^*data from raw suppliers

N,N-Diethylglycine Methyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIETHYLGLYCINE METHYL ESTER

There total 2 articles about N,N-DIETHYLGLYCINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

<(Diethylamino)methylene>cyclohexane (69762-72-7) + bromoacetic acid methyl ester (96-32-2) → N,N-diethylglycine methyl ester (30280-35-4) + 3-Cyclohexyl-3-diethylamino-propionic acid methyl ester

Guidance literature:

With indium; In tetrahydrofuran; for 40h; Yields of byproduct given; Ambient temperature;

DOI:10.1016/0040-4039(95)01241-9

Reference yield:

methanol (67-56-1) + N,N-diethyl-2-diazoacetamide (6112-00-1) → 1-ethyl-2-pyrrolidinone (2687-91-4) + 1-ethyl-4-methylazetidin-2-one (31366-13-9) + N,N-diethylglycine methyl ester (30280-35-4) + 2-methoxy-N,N-diethyl-acetamide (70814-00-5)

Guidance literature:

at 0 ℃; for 0h; Product distribution; Irradiation; variuos temp.;

DOI:10.1021/jo00319a010

Reference yield: 78.0%

N,N-diethylglycine methyl ester (30280-35-4) + 2-chloro-N-(3,5-dimethylphenyl)acetamide (174700-38-0) → 2-(diethylamino)-N-(3,5-dimethyl-phenyl)acetamide

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-3-ium; In toluene; at 145 ℃; for 40h; Glovebox; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201808560

upstream raw materials:

methanol

N,N-diethyl-2-diazoacetamide

<(Diethylamino)methylene>cyclohexane

bromoacetic acid methyl ester

Downstream raw materials:

2-Diethylamino-3-phenyl-succinic acid dimethyl ester

3-(Ethyl-methoxycarbonylmethyl-amino)-2-phenyl-butyric acid methyl ester

perfluoro(N-ethylmorpholine)

perfluoro(N,N-diethylmethylamine)

Refernces

• 1、 Tomioka, Hideo,Kondo, Masato,Izawa, Yasuji. "Substituent Effects on the Product Distribution in Diazo Amide Photochemistry. Role of Ground-State Conformational Populations". . p. 1090 - 1094. Retrieved 2007/10/02.