N-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]-2-pyridyl]phenylacetamide

Base Information

Chemical Name:N-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]-2-pyridyl]phenylacetamide
CAS No.:303162-74-5
Molecular Formula:C25H23N3OS
Molecular Weight:413.543
Hs Code.:
DSSTox Substance ID:DTXSID40437836
Wikidata:Q82253408
Pharos Ligand ID:WN8FYLNW4QA1
ChEMBL ID:CHEMBL197581
Mol file:303162-74-5.mol

Synonyms:N-[4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]PHENYLACETAMIDE;303162-74-5;CHEMBL197581;SCHEMBL1518934;DTXSID40437836;IKWWNWZDGSCJRW-UHFFFAOYSA-N;BDBM50173627;N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-2-phenyl-acetamide

Suppliers and Price of N-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]-2-pyridyl]phenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]-2-pyridyl]phenylacetamide

Chemical Property:

XLogP3:5.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:413.15618354
Heavy Atom Count:30
Complexity:553

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)CC3=CC=CC=C3)C4=CC=CC(=C4)C

Technology Process of N-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]-2-pyridyl]phenylacetamide

There total 6 articles about N-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]-2-pyridyl]phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 303162-39-2
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine

: 103-80-0
phenylacetyl chloride

: 303162-74-5
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]phenylacetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm050165o

Reference yield: 67.0%

: 303162-39-2
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine

: 144-55-8
sodium hydrogencarbonate

: 103-80-0
phenylacetyl chloride

: 303162-74-5
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]phenylacetamide

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 303162-37-0
2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone

: 303162-74-5
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Br₂; AcOH / 3 h / 80 °C

2: 60 percent / dimethylformamide / 14 h / 20 °C

3: 88 percent / Et₃N / tetrahydrofuran / 1 h / 20 °C

With bromine; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o