N-alpha-Benzyl-L-alanine methyl ester

Base Information

• Chemical Name: N-alpha-Benzyl-L-alanine methyl ester
• CAS No.: 31022-10-3
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol file: 31022-10-3.mol

Synonyms:Methyl N-benzyl-L-alaninate;(S)-METHYL2-(BENZYLAMINO)PROPANOATE;(S)-Methyl 2-(benzylamino)propanoate;

Chemical Property of N-alpha-Benzyl-L-alanine methyl ester

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Boiling Point: 271℃
• Flash Point: 118℃
• PSA: 38.33000
• Density: 1.047
• LogP: 1.72860
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-Methyl2-(benzylamino)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-alpha-Benzyl-L-alanine methyl ester

There total 21 articles about N-alpha-Benzyl-L-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

L-alanine methyl ester hydrochloride (2491-20-5) + benzaldehyde (100-52-7) → N-benzyl-L-alanine methyl ester (31022-10-3)

Guidance literature:

L-alanine methyl ester hydrochloride; benzaldehyde; With triethylamine; In methanol; at 20 ℃; for 1.5h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo302018a

Reference yield: 80.0%

L-Alanine methyl ester (10065-72-2) + benzaldehyde (100-52-7) → N-benzyl-L-alanine methyl ester (31022-10-3)

Guidance literature:

With sodium tetrahydroborate;

Reference yield: 77.3%

methanol (67-56-1) + (4S,5R)-1-((R)-2-Benzylamino-propionyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one (176018-06-7) → (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one (92841-65-1) + N-benzyl D-alanine methyl ester (120571-58-6) + N-benzyl-L-alanine methyl ester (31022-10-3)

Guidance literature:

With triethylamine; for 23h; Title compound not separated from byproducts; Heating;

DOI:10.1016/S0040-4020(01)00550-6

upstream raw materials:

diazomethane

N-benzyl-(S)-alanine

2-dibenzylamino-propionic acid methyl ester

sodium methylate

Downstream raw materials:

N-benzyl-N-((1S)-1-methoxycarbonyl)ethyl-3-aminopyrazine-2-carboxamide

methyl (2S)-2-[benzyl(methyl)amino]propanoate

methyl (S)-2-[(N-benzyl)-(N-t-butoxycarbonyl)amino]propanoate

(S)-2-(Benzyl-benzyloxycarbonyl-amino)-propionic acid methyl ester