2,2,2-TRIFLUORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE

Base Information

• Chemical Name: 2,2,2-TRIFLUORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE
• CAS No.: 319-76-6
• Molecular Formula: C12H11F3N2O
• Molecular Weight: 256.227
• Mol file: 319-76-6.mol

Synonyms:2,2,2-Trifluoro-N-[2-(1H-indol-3-yl)-ethyl]-acetamide;ω-N-Trifluoracetyltryptamin;N-[2-(1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide;N-(trifluoroacetyl)tryptamine;Nb-trifluoroacetyltryptamine;N-trifluoroacetyltryptamine;

Chemical Property of 2,2,2-TRIFLUORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE

Chemical Property:

• Melting Point: 92 - 93 °C
• PSA: 44.89000
• LogP: 2.77980

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-TRIFLUORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE

There total 4 articles about 2,2,2-TRIFLUORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

methoxybenzene (100-66-3) + 1-hydroxy-Nb-trifluoroacetyltryptamine (180910-54-7) → N-(2-(1H-indol-3-yl)ethyl)-2,2,2-trifluoroacetamide (319-76-6) + (3a,8a-cis)-1,2,3,3a,8,8a-hexahydro-1-trifluoroacetyl-3a-[3-(Nb-trifluoroacetyl)aminoethylindol-1-yl]pyrrolo[2,3-b]indole + (3a,8a-cis)-1,2,3,3a,8,8a-hexahydro-3a-(4-methoxyphenyl)-1-trifluoroacetylpyrrolo[2,3-b]indole + 1-trifluoroacety-2,3-dihydropyrrolo<2,3-b>indole

Guidance literature:

With methanesulfonyl chloride; triethylamine; In chloroform; at 0 ℃; for 1h;

DOI:10.3987/COM-16-S(S)53

Reference yield: 15.0%

1,2,3-trimethoxybenzene (634-36-6) + methanesulfonyl chloride (124-63-0) + 1-hydroxy-Nb-trifluoroacetyltryptamine (180910-54-7) → N-(2-(1H-indol-3-yl)ethyl)-2,2,2-trifluoroacetamide (319-76-6) + (3a,8a-cis)-1,2,3,3a,8,8a-hexahydro-1-trifluoroacetyl-3a-(2,3,4-trimethoxyphenyl)pyrrolo[2,3-b]indole + (3a,8a-cis)-1,2,3,3a,8,8a-hexahydro-1-trifluoroacetyl-3a-[3-(Nb-trifluoroacetyl)aminoethylindol-1-yl]pyrrolo[2,3-b]indole + 1-trifluoroacety-2,3-dihydropyrrolo<2,3-b>indole + 6-mesyloxy-Nb-trifluoroacetyltryptamine (259534-81-1)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 1h;

DOI:10.3987/COM-16-S(S)53

Reference yield: 8.0%

methanesulfonyl chloride (124-63-0) + 1-hydroxy-Nb-trifluoroacetyltryptamine (180910-54-7) + phenol (108-95-2,27073-41-2) → N-(2-(1H-indol-3-yl)ethyl)-2,2,2-trifluoroacetamide (319-76-6) + (3a,8a-cis)-1,2,3,3a,8,8a-hexahydro-1-trifluoroacetyl-3a-[3-(Nb-trifluoroacetyl)aminoethylindol-1-yl]pyrrolo[2,3-b]indole + (3a,8a-cis)-1,2,3,3a,8,8a-hexahydro-3a-(4-hydroxyphenyl)-1-trifluoroacetylpyrrolo[2,3-b]indole + (3a,8a-cis)-1,2,3,3a,8,8a-hexahydro-3a-(2-hydroxyphenyl)-1-trifluoroacetylpyrrolo[2,3-b]indole + 6-mesyloxy-Nb-trifluoroacetyltryptamine (259534-81-1)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 1h;

DOI:10.3987/COM-16-S(S)53

upstream raw materials:

indole

1-hydroxy-Nb-trifluoroacetyltryptamine

methoxybenzene

1,2,3-trimethoxybenzene

Downstream raw materials:

prenyl bromide

3-(2-aminoethyl)-indole-1-carboxylic acid tert-butyl ester

N-formyl-2-(3-trifluoracetylaminopropionyl)aniline

N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide