N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide
• CAS No.: 148149-00-2
• Molecular Formula: C₁₁H₁₁F₃N₂O₂
• Molecular Weight: 260.216
• Mol file: 148149-00-2.mol

Synonyms:N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide

Chemical Property of N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide

There total 4 articles about N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl trifluoroacetate, (383-63-1) + kynuramine (363-36-0) → N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide (148149-00-2)

Guidance literature:

In methanol; for 4h; Ambient temperature;

DOI:10.1055/s-1994-25446

Reference yield: 78.46%

N-formyl-2-(3-trifluoracetylaminopropionyl)aniline (1280190-67-1) → N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide (148149-00-2)

Guidance literature:

With hydrogenchloride; water; In methanol; for 1h; Reflux;

DOI:10.1039/c0cc04827e

Reference yield:

N-(2-(1H-indol-3-yl)ethyl)-2,2,2-trifluoroacetamide (319-76-6) → N-(3-(2-aminophenyl)-3-oxopropyl)-2,2,2-trifluoroacetamide (148149-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium periodate / methanol; water / 0 - 20 °C

2: hydrogenchloride; water / methanol / 1 h / Reflux

With hydrogenchloride; sodium periodate; water; In methanol; water;

DOI:10.1039/c0cc04827e

upstream raw materials:

ethyl trifluoroacetate,

kynuramine

tryptamine

N-formyl-2-(3-trifluoracetylaminopropionyl)aniline

Downstream raw materials:

6-<2-(3-trifluoroacetamidopropanoyl)anilino>-5,8-quinoline quinone

4-(2-(3-trifluoroacetylamino)propionylphenylamino)-9-(2-trifluoroacetylamino )ethylacridine-1,2-dione

2,2,2-Trifluoro-N-{3-[2-(4-methoxy-5,8-dioxo-5,8-dihydro-quinolin-6-ylamino)-phenyl]-3-oxo-propyl}-acetamide

ascididemin