N-ethylpyridin-3-amine

Base Information

• Chemical Name: N-ethylpyridin-3-amine
• CAS No.: 32405-70-2
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 834-797-9
• Nikkaji Number: J754.674B
• Mol file: 32405-70-2.mol

Synonyms:N-ethylpyridin-3-amine;32405-70-2;3-(ethylamino)pyridine;3-ethylaminopyridine;pyridin-3-yl-ethylamine;SCHEMBL1355489;JNHZPXFARRJZQR-UHFFFAOYSA-N;AMY19453;MFCD11140216;AKOS000228000;SB52312;BS-13058;CS-0089664;FT-0733020;EN300-66883;C15578;Z334882416

Chemical Property of N-ethylpyridin-3-amine

Chemical Property:

• Boiling Point: 229.2±13.0 °C(Predicted)
• PKA: 6.54±0.11(Predicted)
• PSA: 24.92000
• Density: 1.029±0.06 g/cm3(Predicted)
• LogP: 1.58640
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 73.3

Purity/Quality:

97% ^*data from raw suppliers

N-Ethylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC1=CN=CC=C1

Technology Process of N-ethylpyridin-3-amine

There total 11 articles about N-ethylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-Bromopyridine (626-55-1,163928-56-1) + ethanamine hydrochloride (557-66-4) → N-ethyl-3-aminopyridine (32405-70-2,1199266-73-3)

Guidance literature:

With (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; sodium t-butanolate; In 1,4-dioxane; for 12h; Inert atmosphere; Glovebox; Heating;

DOI:10.1021/ol501739g

Reference yield: 83.0%

pyridin-3-ylamine (462-08-8) + acetic acid (64-19-7,77671-22-8) → N-ethyl-3-aminopyridine (32405-70-2,1199266-73-3)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 40 - 50 ℃; for 0.5h; chemoselective reaction;

DOI:10.3184/174751911X13190991845013

Reference yield: 79.0%

3-Chloropyridine (626-60-8) + ethylamine (75-04-7,85404-22-4) → N-ethyl-3-aminopyridine (32405-70-2,1199266-73-3)

Guidance literature:

With Pd₂(dba)4; potassium tert-butylate; C₄₀H₆₆P₂; In tetrahydrofuran; at 20 ℃; for 1.5h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.joc.0c01771

upstream raw materials:

3-Bromopyridine

ethylamine

pyridin-3-ylamine

ethanol

Refernces

• 1、 Rodstein, Ilja,Prendes, Daniel Sowa,Wickert, Leon,Paa?en, Maurice,Gessner, Viktoria H.. "Selective Pd-catalyzed monoarylation of small primary alkyl amines through backbone-modification in ylide-functionalized phosphines (YPhos)". . p. 14674 - 14683. Retrieved 2020/12/29.
• 2、 Green, Rebecca A.,Hartwig, John F.. "Palladium-catalyzed amination of aryl chlorides and bromides with ammonium salts". supporting information. p. 4388 - 4391. Retrieved 2015/01/08.