4,5-dichloro-2-ethyl-3(2H)-pyridazinone

Base Information

• Chemical Name: 4,5-dichloro-2-ethyl-3(2H)-pyridazinone
• CAS No.: 33098-10-1
• Molecular Formula: C6H6Cl2N2O
• Molecular Weight: 193.032
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID30350287
• Nikkaji Number: J1.048.530D
• Wikidata: Q82126146
• Mol file: 33098-10-1.mol

Synonyms:33098-10-1;4,5-dichloro-2-ethyl-3(2H)-pyridazinone;4,5-dichloro-2-ethylpyridazin-3-one;4,5-dichloro-2-ethyl-2,3-dihydropyridazin-3-one;4,5-dichloro-2-ethylpyridazin-3(2H)-one;MFCD00793799;TimTec1_004656;SCHEMBL980058;DTXSID30350287;HUBYCKLNOVDZDN-UHFFFAOYSA-N;HMS1547D14;AKOS008947811;4,5-dichloro-2-ethyl-3(2H)pyridazinone;4,5-dichloro-2-ethyl-2H-pyridazin-3-one;CS-0314107;E78693;11K-931

Chemical Property of 4,5-dichloro-2-ethyl-3(2H)-pyridazinone

Chemical Property:

• PSA: 34.89000
• LogP: 1.57000
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 191.9857182
• Heavy Atom Count: 11
• Complexity: 247

Purity/Quality:

97% ^*data from raw suppliers

4,5-Dichloro-2-ethyl-3(2H)-pyridazinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C(=O)C(=C(C=N1)Cl)Cl

Technology Process of 4,5-dichloro-2-ethyl-3(2H)-pyridazinone

There total 3 articles about 4,5-dichloro-2-ethyl-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

ethyl bromide (74-96-4) + 4,5-dichloro-2H-pyridazin-3-one (932-22-9) → 4,5-dichloro-2-ethylpyridazin-3(2H)-one (33098-10-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.1c01294

Reference yield:

4,5-dichloro-2H-pyridazin-3-one (932-22-9) + ethyl iodide (75-03-6) → 4,5-dichloro-2-ethylpyridazin-3(2H)-one (33098-10-1)

Guidance literature:

With potassium carbonate; In acetone; at 55 ℃; for 8h;

Reference yield:

4,5-dichloro-2H-pyridazin-3-one (932-22-9) → 4,5-dichloro-2-ethylpyridazin-3(2H)-one (33098-10-1)

Guidance literature:

4,5-dichloro-2H-pyridazin-3-one; With tetrabutylammomium bromide; potassium hydroxide; In acetonitrile; Reflux;

ethyl halide; In acetonitrile; for 5h; Reflux;

DOI:10.1055/s-0037-1609338

upstream raw materials:

ethyl bromide

4,5-dichloro-2H-pyridazin-3-one

ethyl iodide

Downstream raw materials:

7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-ethyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

ethyl 2-(4'-chloro-2'-ethyl-3'-oxopyridazin-5'-yl)-2-(4''-nitrophenyl)propanoate

4-Chloro-2-ethyl-5-methylamino-2H-pyridazin-3-one

5-Chloro-2-ethyl-4-methylamino-2H-pyridazin-3-one