2,4,6-trimethylbenzoic anhydride

Base Information

• Chemical Name: 2,4,6-trimethylbenzoic anhydride
• CAS No.: 5745-51-7
• Molecular Formula: C20H22O3
• Molecular Weight: 310.393
• Mol file: 5745-51-7.mol

Synonyms:

Chemical Property of 2,4,6-trimethylbenzoic anhydride

Chemical Property:

• Vapor Pressure: 4.23E-09mmHg at 25°C
• Boiling Point: 472.6°C at 760 mmHg
• Flash Point: 224.9°C
• Density: 1.091g/cm³

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,6-trimethylbenzoic anhydride

There total 14 articles about 2,4,6-trimethylbenzoic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

mesitylenecarboxylic acid (480-63-7) → 2,4,6-trimethyl-benzoic acid-anhydride (5745-51-7)

Guidance literature:

With triethylamine; 3-diphenyloxyphosphinyl-2-oxazolidinone; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)91572-8

Reference yield: 78.0%

mesitylenecarboxylic acid (480-63-7) + Diphenyl 2-oxo-3-oxazolinylphosphonate (78605-38-6) → 2,4,6-trimethyl-benzoic acid-anhydride (5745-51-7) + 3-(2,4,6-trimethylbenzoyl)-2-oxazolone (89332-62-7)

Guidance literature:

With triethylamine; In acetonitrile; for 10h; Heating;

DOI:10.1016/S0040-4020(01)91572-8

Reference yield: 77.0%

iodomesitylene (4028-63-1) + carbon monoxide (201230-82-2) → 2,4,6-trimethyl-benzoic acid-anhydride (5745-51-7)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; water; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 20 - 115 ℃; for 48h; under 760.051 Torr; Inert atmosphere; Autoclave;

DOI:10.1039/c2cc16611a

upstream raw materials:

pyridine

potassium cyanide

mesitylene-2-carboxylic acid chloride

(carbonic acid ethyl ester)-(2,4,6-trimethyl-benzoic acid )-anhydride

Downstream raw materials:

dimesityl ketone

3-phenylpropionic acid 3-phenylpropyl ester

mesitylenecarboxylic acid

2,4,6-trimethylbenzyl alcohol

Refernces

• 1、 Li, Yang,Xue, Dong,Wang, Chao,Liu, Zhao-Tie,Xiao, Jianliang. "Carboxylic acid anhydrides via Pd-catalyzed carbonylation of aryl halides at atmospheric CO pressure". supporting information; experimental part. p. 1320 - 1322. Retrieved 2012/02/04.
• 2、 Makowiec, Slawomir,Rachon, Janusz. "Reactivity of diacyloxyiodobenzenes toward trivalent phosphorus nucleophiles". . p. 352 - 359. Retrieved 2007/10/03.