Aziridine, 2-cyclohexyl-1-[(4-methylphenyl)sulfonyl]-

Base Information

• Chemical Name: Aziridine, 2-cyclohexyl-1-[(4-methylphenyl)sulfonyl]-
• CAS No.: 336784-74-8
• Molecular Formula: C15H21NO2S
• Molecular Weight: 279.403
• DSSTox Substance ID: DTXSID10373075
• Nikkaji Number: J1.495.210A
• Mol file: 336784-74-8.mol

Synonyms:2-Cyclohexyl-1-tosylaziridine;336784-74-8;Aziridine, 2-cyclohexyl-1-[(4-methylphenyl)sulfonyl]-;N-tosyl cyclohexyl aziridine;1-Tosyl-2-cyclohexylaziridine;SCHEMBL8745861;DTXSID10373075;2-CYCLOHEXYL-1-(4-METHYLBENZENESULFONYL)AZIRIDINE

Chemical Property of Aziridine, 2-cyclohexyl-1-[(4-methylphenyl)sulfonyl]-

Chemical Property:

• Melting Point: 94-95 °C
• Boiling Point: 411.0±38.0 °C(Predicted)
• PSA: 45.53000
• Density: 1.225±0.06 g/cm3(Predicted)
• LogP: 3.96690
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 279.12930009
• Heavy Atom Count: 19
• Complexity: 400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)N2CC2C3CCCCC3

Technology Process of Aziridine, 2-cyclohexyl-1-[(4-methylphenyl)sulfonyl]-

There total 14 articles about Aziridine, 2-cyclohexyl-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diiodomethane (75-11-6) + N-(cyclohexylmethylene)-4-methylbenzenesulfonamide (175355-34-7) → 2-cyclohexyl-1-tosylaziridine (336784-74-8)

Guidance literature:

With methyllithium; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol801607r DOI:10.1021/jo802596y

Reference yield: 85.0%

vinylcyclohexane (695-12-5,25498-06-0) + [N-(p-tolylsulfonyl)imino]phenyliodinane (55962-05-5) → 2-cyclohexyl-1-tosylaziridine (336784-74-8)

Guidance literature:

With [Cu(II)(NCCH₃)6][Al{OC(CF₃)3}4]2; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2008.07.162

Reference yield: 75.0%

vinylcyclohexane (695-12-5,25498-06-0) + chloroamine-T (127-65-1) → 2-cyclohexyl-1-tosylaziridine (336784-74-8)

Guidance literature:

vinylcyclohexane; chloroamine-T; With phenyltrimethylammonium tribromide; In acetonitrile; at 21 ℃;

With potassium carbonate; In acetonitrile; at 45 ℃; for 2h;

DOI:10.1021/ja505823s

upstream raw materials:

Chloroiodomethane

(E)-N-cyclohexylmethylene-4-toluenesulfonamide

vinylcyclohexane

N-iodo-N-potassio-p-toluenesulphonamide

Downstream raw materials:

2-cyclohexylaziridine