Dimethyl Bis(hydroxymethyl)malonate

Base Information

• Chemical Name: Dimethyl Bis(hydroxymethyl)malonate
• CAS No.: 35329-73-8
• Molecular Formula: C7H12O6
• Molecular Weight: 192.169
• Mol file: 35329-73-8.mol

Synonyms:

Chemical Property of Dimethyl Bis(hydroxymethyl)malonate

Chemical Property:

• Vapor Pressure: 1.58E-05mmHg at 25°C
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

DimethylBis(hydroxymethyl)malonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dimethyl Bis(hydroxymethyl)malonate is a regent used for the synthesis of HIV-1 protease inhibitors and antiplasmin drugs.

Technology Process of Dimethyl Bis(hydroxymethyl)malonate

There total 1 articles about Dimethyl Bis(hydroxymethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + malonic acid dimethyl ester (108-59-8) → dimethyl 2,2-bis(hydroxymethyl)malonate (35329-73-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; 1,4-dioxane; water; a) from 4 deg C to 6 deg C, 20 min, b) RT, 40 min;

DOI:10.1055/s-1997-1344

Reference yield: 86.0%

dimethyl 2,2-bis(hydroxymethyl)malonate (35329-73-8) + 4-chloro-3-fluorobenzaldehyde (5527-95-7) → 2-(4-chloro-3-fluorophenyl)-5,5-bis(methoxycarbonyl)-1,3-dioxane

Guidance literature:

With toluene-4-sulfonic acid; In di-isopropyl ether; cyclohexane; water; for 2h; Inert atmosphere; Reflux;

Reference yield: 85.0%

dimethyl 2,2-bis(hydroxymethyl)malonate (35329-73-8) + acetone (67-64-1) → 2,2-Dimethyl-[1,3]dioxane-5,5-dicarboxylic acid dimethyl ester (111934-93-1)

Guidance literature:

With toluene-4-sulfonic acid;

DOI:10.1016/j.tetasy.2004.07.047

upstream raw materials:

formaldehyd

malonic acid dimethyl ester

Downstream raw materials:

dimethyl 2-benzyloxycarbonylaminomethyl-1,3-dioxane-5,5-dicarboxylate

2,2-Dimethyl-[1,3]dioxane-5,5-dicarboxylic acid dimethyl ester

methyl 2,2-dimethyl-1,3-dioxane-5-carboxylate