2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylic Acid Dimethyl Ester

Base Information

• Chemical Name: 2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylic Acid Dimethyl Ester
• CAS No.: 111934-93-1
• Molecular Formula: C10H16O6
• Molecular Weight: 232.233
• Mol file: 111934-93-1.mol

Synonyms:2,2-Dimethyl-01,3-dioxane-5,5-dicarboxylic Acid0 Dimethyl Ester;1,3-Dioxane-5,5-dicarboxylic acid,2,2-dimethyl-,dimethyl ester;

Chemical Property of 2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylic Acid Dimethyl Ester

Chemical Property:

• Vapor Pressure: 0.043mmHg at 25°C
• Boiling Point: 238.126oC at 760 mmHg
• Flash Point: 94.88oC
• PSA: 71.06000
• Density: 1.157±0.06 g/cm3(Predicted)
• LogP: 0.10170
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylicAcidDimethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylic Acid Dimethyl Ester (cas# 111934-93-1) is a compound useful in organic synthesis.

Technology Process of 2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylic Acid Dimethyl Ester

There total 3 articles about 2,2-Dimethyl-1,3-dioxane-5,5-dicarboxylic Acid Dimethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dimethyl 2,2-bis(hydroxymethyl)malonate (35329-73-8) + acetone (67-64-1) → 2,2-Dimethyl-[1,3]dioxane-5,5-dicarboxylic acid dimethyl ester (111934-93-1)

Guidance literature:

With toluene-4-sulfonic acid;

DOI:10.1016/j.tetasy.2004.07.047

Reference yield:

dimethyl 2,2-bis(hydroxymethyl)malonate (35329-73-8) + 2,2-dimethoxy-propane (77-76-9) → 2,2-Dimethyl-[1,3]dioxane-5,5-dicarboxylic acid dimethyl ester (111934-93-1)

Guidance literature:

With toluene-4-sulfonic acid; for 54h;

DOI:10.1021/jm960092w

Reference yield:

malonic acid dimethyl ester (108-59-8) → 2,2-Dimethyl-[1,3]dioxane-5,5-dicarboxylic acid dimethyl ester (111934-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / sodium hydrogencarbonate / H₂O

2: 85 percent / p-toluenesulfonic acid

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In water;

DOI:10.1016/j.tetasy.2004.07.047

upstream raw materials:

dimethyl 2,2-bis(hydroxymethyl)malonate

2,2-dimethoxy-propane

acetone

malonic acid dimethyl ester

Downstream raw materials:

2,2-dimethyl-5-hydroxymethyl-1,3-dioxane

2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-N-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

2-(4-{2-[[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-N-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

N-(1-ethylcyclopentyl)-[2-(4-{2-[(2,2-dimethyl[1,3]dioxan-5-yl)methyl](1-methyl-1-phenylethyl)carbamoyl}-4-methylphenyl)-3-hydroxybutyl]-N-(2-hydroxyethyl)benzamide