1-Oxaspiro[2.5]octane-2-carbonitrile

Base Information

• Chemical Name: 1-Oxaspiro[2.5]octane-2-carbonitrile
• CAS No.: 36929-66-5
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.181
• Hs Code.: 2932999099
• Mol file: 36929-66-5.mol

Synonyms:2-oxaspiro[2.5]octanecarbonitrile;2-oxaspiro[2.5]octane-1-carbonitrile;1-oxaspiro[2.5]octan-2-kohlenitrile;1-oxaspiro<2,5>octane-2-carboxylic acid nitrile;1-Oxa-spiro[2.5]octan-2-carbonitril;2-Cyano-1-oxaspiro<2.5>octane;1-oxa-spiro<2.5>-octane-2-carbonitrile;

Chemical Property of 1-Oxaspiro[2.5]octane-2-carbonitrile

Chemical Property:

• PSA: 36.32000
• LogP: 1.61168
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-Oxaspiro[2.5]octane-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxaspiro[2.5]octane-2-carbonitrile

There total 2 articles about 1-Oxaspiro[2.5]octane-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

→ 1-oxaspiro<2,5>octane-2-carboxylic acid nitrile (36929-66-5,500899-63-8,500899-64-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield: 85.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + chloroacetonitrile (107-14-2) → 1-oxaspiro<2,5>octane-2-carboxylic acid nitrile (36929-66-5,500899-63-8,500899-64-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 - 30 ℃; for 0.416667h;

Reference yield: 90.0%

1-oxaspiro<2,5>octane-2-carboxylic acid nitrile (36929-66-5,500899-63-8,500899-64-9) → α-(1-Fluorocyclohexyl)-α-hydroxyacetonitrile (699-43-4)

Guidance literature:

With pyridine; hydrogen fluoride; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/S0022-1139(00)82265-4

upstream raw materials:

cyclohexanone

chloroacetonitrile

Downstream raw materials:

1-cyclohexene-1-carboxaldehyde

1-amino-2-cyclohexylethan-2-ol

1-Hydroxy-1-<1-chlor-cyclohexyl-(1)>-acetonitril

1-(2-aminoethyl)cyclohexanol

Refernces

• 1、 Jonczyk,Gadaj. "Expedient synthesis of glycidonitriles by darzens condensation of α-halogenonitriles with aldehydes and ketones". . p. 1595 - 1610. Retrieved 2008/09/17.
• 2、 Mongelli,Animati,D'Alessio,Zuliani,Gandolfi. "1-Fluorocycloalkanecarboxylic acids in the synthesis of 16-achiral 16-fluoro-9a-carbaprostacyclin derivatives". . p. 310 - 313. Retrieved 2007/10/02.